Effects of intravitreal triamcinolone acetonide injection with and without preservative

被引：53

作者：

Maia, Mauricio ^{[1
]}

Farah, Michel Eid ^{[1
]}

Belfort, Rubens N. ^{[1
]}

Penha, Fernando Marcondes ^{[1
]}

Lima, Cio A. S. Filho ^{[1
]}

Aggio, Fabio Bom ^{[1
]}

Belfort, Rubens, Jr. ^{[1
]}

机构：

[1] Univ Fed Sao Paulo, Dept Ophthalmol, Vis Inst, BR-04023062 Sao Paulo, Brazil

来源：

BRITISH JOURNAL OF OPHTHALMOLOGY | 2007年 / 91卷 / 09期

关键词：

D O I：

10.1136/bjo.2007.115386

中图分类号：

R77 [眼科学];

学科分类号：

100212 [眼科学];

摘要：

Aims: To evaluate the effects of intravitreal injection of preservative-free triamcinolone acetonide (PFTA) and TA containing preservative (KE). Methods: A retrospective review was conducted of 646 intravitreal 4 mg/0.1 ml steroid injections in 471 eyes. A total of 577 intravitreal injections of PFTA and 69 injections of KE were administered in non-randomised eyes. No supernatant removal from KE was performed. Non-infectious endophthalmitis was defined as pseudohypopyon/hypopyon with or without an inflammatory reaction that regressed after steroid eye drop instillation. Ocular hypertension was defined as more than 23 mm Hg with Goldman applanation tonometry. Patients were followed and examined 1, 7 and 28 days, and 3, 4, 6 and 12 months after injection and annually thereafter. Statistical analysis was performed using Fisher's exact test and X2 test. p Values <0.05 were considered significant. Results: Both groups did not differ in demographics (p>0.05). Follow-up ranged from 6 to 57 months (mean 13, SD 7.5). Ocular hypertension was present in 127 eyes (20%), but both groups did not differ significantly (p = 0.167). Four eyes (3.15%) required trabeculectomy. Non-infectious endophthalmitis developed in 12 eyes (1.9%) and varied significantly in both groups (p = 0.005). One eye developed bacterial endophthalmitis (0.15%). Conclusions: Non-infectious endophthalmitis was observed significantly more often after KE injections (7.3%) than after PFTA injections (1.2%) (p<0.05). An inflammatory reaction was more clinically relevant in the KE group than in the PFTA group.

引用

页码：1122 / 1124

页数：3

共 17 条

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