Expression of CD40 in the brain of Alzheimer's disease and other neurological diseases

被引：114

作者：

Togo, T

Akiyama, H

Kondo, H

Ikeda, K

Kato, M

Iseki, E

Kosaka, K

机构：

[1] Psychiat Res Inst Tokyo, Setagaya Ku, Tokyo 1568585, Japan

[2] Yokohama City Univ, Dept Psychiat, Yokohama, Kanagawa 232, Japan

[3] Soga Hosp, Odawara, Kanagawa, Japan

来源：

BRAIN RESEARCH | 2000年 / 885卷 / 01期

关键词：

microglia; blood vessel; amyloid beta-protein; inflammation;

D O I：

10.1016/S0006-8993(00)02984-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

We have investigated immunohistochemically the expression of CD40 in post-mortem human brain tissues. In control brain, the blood vessels were stained weakly for CD40. Vascular expression of CD40 was enhanced in the lesions of Alzheimer's disease and some other neurological diseases. In such diseases, reactive microglia were also positive for CD40. The results of this study suggest that CD40 expression by microglia is up-regulated upon a variety of brain insults and is not limited to lesions with amyloid beta -protein deposits. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：117 / 121

页数：5

共 21 条

[1]

CD40 EXPRESSION BY HUMAN MONOCYTES - REGULATION BY CYTOKINES AND ACTIVATION OF MONOCYTES BY THE LIGAND FOR CD40 [J].