Adaptation of a multi-drug resistant strain of Plasmodium falciparum from Peru to Aotus lemurinus griseimembra, A-nancymaae, and A-vociferans monkeys

被引:3
作者
Collins, William E.
Sullivan, Joann S.
Hall, Patrice
Ruebush, Trenton K., II
Williams, Allison
Grady, Katharine K.
Bounngaseng, Amy
Nace, Douglas
Williams, Tyrone
Huber, Curtis
Galland, G. Gale
Barnwell, John W.
Sullivan, James J.
机构
[1] Ctr Dis Control & Prevent, Div Parasit Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, Natl Ctr Preparedness Detect & Control Infect Dis, Chamblee, GA 30341 USA
[2] Ctr Dis Control & Prevent, Animal Resources Branch, Natl Ctr Preparedness Detect & Control Infect Dis, Chamblee, GA 30341 USA
[3] Dept Hlth & Human Serv, Publ Hlth Serv, Atlanta, GA USA
[4] Atlanta Res & Educ Fdn, Decatur, GA USA
[5] US Agcy Int Dev, Bur Global Hlth, Washington, DC 20523 USA
关键词
D O I
10.4269/ajtmh.2007.77.261
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
A strain of Plasmodium falciparum from Peru was adapted to splenectomized Aotus nancymaae and Aotus vociferans monkeys. The Peru 134/CDC strain of P. falciparum was shown to be resistant to treatment with chloroquine in monkeys and partially resistant to mefloquine and malarone. Genetic mutations in crt, dhfr, dhps, and cytochrome b genes conferring drug resistance were also determined for this Peruvian strain of P. falciparum.
引用
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页码:261 / 265
页数:5
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