The multiple nuclear functions of BRCA1: transcription, ubiquitination and DNA repair

被引：181

作者：

Starita, LM

Parvin, JD

机构：

[1] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

[2] Brigham & Womens Hosp, Boston, MA 02115 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2003年 / 15卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0955-0674(03)00042-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Interest in BRCA1 stems from its role as a tumour suppressor in breast and ovarian cancer. Intensive research in BRCA1 has revealed little about its specific role in cancer; rather, this protein has been implicated in a multitude of important cellular processes. The diverse biochemical activities of BRCA1 combine to protect the genome from damage. New data reveal that BRCA1 transcriptionally regulates some DNA-repair genes, and, in addition, new roles for BRCA1 have been identified in heterochromatin formation on the X chromosome, double-strand-break repair, and ubiquitination. These diverse activities of BRCA1 may be linked in a single pathway, or BRCA1 might function in multiple nuclear processes.

引用

页码：345 / 350

页数：6

共 54 条

[1] BRCA1 expression restores radiation resistance in BRCA1-defective cancer cells through enhancement of transcription-coupled DNA repair [J].

Abbott, DW ;

Thompson, ME ;

Robinson-Benion, C ;

Tomlinson, G ;

Jensen, RA ;

Holt, JT .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (26) :18808-18812

[2] BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase a [J].

Anderson, SE ;

Schlegel, BP ;

Nakajima, T ;

Wolpin, ES ;

Parvin, JD .

NATURE GENETICS, 1998, 19 (03) :254-256

[3] BRCA1 regulates the interferon γ-mediated apoptotic response [J].

Andrews, HN ;

Mullan, PB ;

McWilliams, S ;

Sebelova, S ;

Quinn, JE ;

Gilmore, PM ;

McCabe, N ;

Pace, A ;

Koller, B ;

Johnston, PG ;

Haber, DA ;

Harkin, DP .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (29) :26225-26232

[4] Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX [J].

Bassing, CH ;

Chua, KF ;

Sekiguchi, J ;

Suh, H ;

Whitlow, SR ;

Fleming, JC ;

Monroe, BC ;

Ciccone, DN ;

Yan, C ;

Vlasakova, K ;

Livingston, DM ;

Ferguson, DO ;

Scully, R ;

Alt, FW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (12) :8173-8178

[5] BRCA1 is associated with a human SWI/SNF-related complex: Linking chromatin remodeling to breast cancer [J].

Bochar, DA ;

Wang, L ;

Beniya, H ;

Kinev, A ;

Xue, YT ;

Lane, WS ;

Wang, WD ;

Kashanchi, F ;

Shiekhattar, R .

CELL, 2000, 102 (02) :257-265

[6] Structure of a BRCA1-BARD1 heterodimeric RING-RING complex [J].

Brzovic, PS ;

Rajagopal, P ;

Hoyt, DW ;

King, MC ;

Klevit, RE .

NATURE STRUCTURAL BIOLOGY, 2001, 8 (10) :833-837

[7] Genomic instability in mice lacking histone H2AX [J].

Celeste, A ;

Petersen, S ;

Romanienko, PJ ;

Fernandez-Capetillo, O ;

Chen, HT ;

Sedelnikova, OA ;

Reina-San-Martin, B ;

Coppola, V ;

Meffre, E ;

Difilippantonio, MJ ;

Redon, C ;

Pilch, DR ;

Olaru, A ;

Eckhaus, M ;

Camerini-Otero, RD ;

Tessarollo, L ;

Livak, F ;

Manova, K ;

Bonner, WM ;

Nussenzweig, MC ;

Nussenzweig, A .

SCIENCE, 2002, 296 (5569) :922-927

[8] Transcriptional activation by BRCA1 [J].

Chapman, MS ;

Verma, IM .

NATURE, 1996, 382 (6593) :678-679

[9] The yeast HPR1 gene has a functional role in transcriptional elongation that uncovers a novel source of genome instability [J].

Chávez, S ;

Aguilera, A .

GENES & DEVELOPMENT, 1997, 11 (24) :3459-3470

[10] Autoubiquitination of the BRCA1-BARD1 RING ubiquitin ligase [J].

Chen, A ;

Kleiman, FE ;

Manley, JL ;

Ouchi, T ;

Pan, ZQ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (24) :22085-22092

← 1 2 3 4 5 6 →