Drug loading of nanoporous TiO2 films

被引:46
作者
Ayon, Arturo A. [1 ]
Cantu, Michael
Chava, Kalpana
Agrawal, C. Mauli
Feldman, Marc D.
Johnson, Dave
Patel, Devang
Marton, Denes
Shi, Emily
机构
[1] Univ Texas, Dept Elect & Comp Engn, MEMS Res Lab, San Antonio, TX 78285 USA
[2] Univ Texas, Dept Mech Engn, San Antonio, TX 78285 USA
[3] Univ Texas, Dept Biol, San Antonio, TX 78285 USA
[4] Univ Texas, Coll Engn, San Antonio, TX 78285 USA
[5] Univ Texas, Hlth Sci Ctr, Dept Radiol, San Antonio, TX 78285 USA
[6] Univ Texas, Dept Chem, San Antonio, TX 78285 USA
[7] Univ Texas, Dept Elect Engn, Austin, TX 78712 USA
关键词
D O I
10.1088/1748-6041/1/4/L01
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
The loading of therapeutic amounts of drug on a nanoporous TiO2 surface is described. This novel drug-loading scheme on a biocompatible surface, when employed on medical implants, will benefit patients who require the deployment of drug-eluting implants. Anticoagulants, analgesics and antibiotics can be considered on the associated implants for drug delivery during the time of maximal pain or risk for patients undergoing orthopedic procedures. Therefore, this scheme will maximize the chances of patient recovery.
引用
收藏
页码:L11 / L15
页数:5
相关论文
共 29 条
[1]  
Chastain J., 1995, HDB XRAY PHOTOELECTR
[2]   Randomized study to assess the effectiveness of slow- and moderate-release polymer-based paclitaxel-eluting stents for coronary artery lesions [J].
Colombo, A ;
Drzewiecki, J ;
Banning, A ;
Grube, E ;
Hauptmann, K ;
Silber, S ;
Dudek, D ;
Fort, S ;
Schiele, F ;
Zmudka, K ;
Guagliumi, G ;
Russell, ME .
CIRCULATION, 2003, 108 (07) :788-794
[3]  
Dai SY, 2003, CHINESE PHYS LETT, V20, P953, DOI 10.1088/0256-307X/20/6/351
[4]  
DEB SK, 1997, 26 IEEE PHOTOVOLTAIC
[5]   Pathological analysis of local delivery of paclitaxel via a polymer-coated stent [J].
Farb, A ;
Heller, PF ;
Shroff, S ;
Cheng, L ;
Kolodgie, FD ;
Carter, AJ ;
Scott, DS ;
Froehlich, J ;
Virmani, R .
CIRCULATION, 2001, 104 (04) :473-479
[6]   Effect of humidity on the ac conductivity of nanoporous TiO2 [J].
Garcia-Belmonte, G ;
Kytin, V ;
Dittrich, T ;
Bisquert, J .
JOURNAL OF APPLIED PHYSICS, 2003, 94 (08) :5261-5264
[7]   Metal-oxide films with magnetically-modulated nanoporous architectures [J].
Grimes, CA ;
Singh, RS ;
Dickey, EC ;
Varghese, OK .
JOURNAL OF MATERIALS RESEARCH, 2001, 16 (06) :1686-1693
[8]   Incremental cost-effectiveness of drug-eluting stents compared with a third-generation bare-metal stent in a real-world setting: randomised Basel Stent Kosten Effektivitats Trial (BASKET) [J].
Kaiser, C ;
Brunner-LaRocca, HP ;
Buser, PT ;
Bonetti, PO ;
Osswald, S ;
Linka, A ;
Bernheim, A ;
Zutter, A ;
Zellweger, M ;
Grize, L ;
Pfisterer, ME .
LANCET, 2005, 366 (9489) :921-929
[9]   ORDERED MESOPOROUS MOLECULAR-SIEVES SYNTHESIZED BY A LIQUID-CRYSTAL TEMPLATE MECHANISM [J].
KRESGE, CT ;
LEONOWICZ, ME ;
ROTH, WJ ;
VARTULI, JC ;
BECK, JS .
NATURE, 1992, 359 (6397) :710-712
[10]   Synthesis of mesostructured nickel oxide with silica [J].
Liu, XH ;
Chun, CM ;
Aksay, IA ;
Shih, WH .
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 2000, 39 (03) :684-692