Magnetoimpedance biosensor for Fe3O4 nanoparticle intracellular uptake evaluation

被引：68

作者：

Kumar, A. ^{[1
]}

Mohapatra, S.

Fal-Miyar, V.

Cerdeira, A.

Garcia, J. A.

Srikanth, H.

Gass, J.

Kurlyandskaya, G. V.

机构：

[1] Univ S Florida, Dept Internal Med, Div Clin Immunol & Allergy, Tampa, FL 33612 USA

[2] Univ Oviedo, Dept Phys, Oviedo 33007, Spain

[3] Univ S Florida, Dept Phys, Tampa, FL 33620 USA

[4] Univ Basque Country UPV EHU, Dept Elect & Elect, Bilbao 48080, Spain

来源：

APPLIED PHYSICS LETTERS | 2007年 / 91卷 / 14期

关键词：

D O I：

10.1063/1.2790370

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

Iron oxide (Fe3O4) nonspecific nanoparticles of 30 nm are embedded inside human embryonic kidney (HEK 293) cells by intracellular uptake with a concentration of similar to 10(5) particles/cell. An amorphous ribbon of Co64.5Fe2.5Cr3Si15B15 exhibiting large magnetoimpedance (MI) serves as the sensing element. The presence of fringing fields of the nanoparticles changes the superposition of the constant applied field and the alternating field created by a current flowing through the ribbon that can be detected as a change in MI. This response is clearly dependent on the presence of the magnetic nanoparticles inside the cells and on the value of the external field. (C) 2007 American Institute of Physics.

引用

页数：3

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