A comprehensive radiation hybrid map of the bovine genome comprising 5593 loci

被引：70

作者：

Itoh, T

Watanabe, T

Ihara, N

Mariani, P

Beattie, CW

Sugimoto, Y

Takasuga, A ^{[1
]}

机构：

[1] Shirakawa Inst Anim Genet, Fukushima 9618061, Japan

[2] Livestock Improvement Assoc Japan Inc, Maebashi, Gumma 3510121, Japan

[3] FPTP, CERSA, Palazzo LITA, I-20090 Segrate, MI, Italy

[4] Univ Nevada, Dept Anim Biotechnol, Reno, NV 89557 USA

来源：

GENOMICS | 2005年 / 85卷 / 04期

关键词：

radiation hybrid map; cattle; microsatellite; EST; comparative map;

D O I：

10.1016/j.ygeno.2004.12.007

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A bovine whole genome 7000-rad radiation hybrid (RH) panel, SUNbRH(7000-rad), was constructed to build a high-resolution RH map. The Shirakawa-USDA linkage map served as a scaffold to construct a framework map of 3216 microsatellites on which 2377 ESTs were ordered. The resulting RH map provided essentially complete coverage across the genome, with 1 cR(7000) corresponding to 114 kb, and a cattle-human comparative map of 1716 bovine genes and sequences annotated in the human genome, which covered 79 and 72% of the bovine and human genomes, respectively. We then integrated the bovine RH and comparative maps with BAC fingerprint information in http://www.bcgsc.ca/ lab/mapping/bovine to construct a detailed, BAC-based physical map covering a reported 40-cM quantitative trait locus region for intramuscular fat or "marbling" on BTA 4. In summary, the new, high-resolution SUNbRH(7000-rad), comparative, Shirakawa-USDA linkage, and BAC fingerprint maps provide a set of genomic tools for fine mapping regions of interest in cattle. (c) 2005 Elsevier Inc. All rights reserved.

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页码：413 / 424

页数：12

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