Transcription factor regulation of B lineage commitment

被引：39

作者：

Kee, BL ^{[1
]}

Murre, C ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Biol, La Jolla, CA 92093 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2001年 / 13卷 / 02期

关键词：

D O I：

10.1016/S0952-7915(00)00202-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The past year has provided insight into the mechanisms by which multipotent progenitors commit to differentiation through the B lymphocyte lineage. Mice lacking the Pax5 gene develop pro-B lymphocytes but these cells are not uniquely committed to the B lineage as they can give rise to all hematopoietic cell types if cultured under appropriate conditions. Regulators of lymphocyte proliferation and survival have also been identified that may allow lymphocytes to respond to information provided by the external environment.

引用

页码：180 / 185

页数：6

共 54 条

[1]

Åkerblad P, 1999, MOL CELL BIOL, V19, P392

[2]

Anderson MK, 1999, DEVELOPMENT, V126, P3131

[3] Both E12 and E47 allow commitment to the B cell lineage [J].

Bain, G ;

Maandag, ECR ;

Riele, HPJT ;

Feeney, AJ ;

Sheehy, A ;

Schlissel, M ;

Shinton, SA ;

Hardy, RR ;

Murre, C .

IMMUNITY, 1997, 6 (02) :145-154

[4] E2A deficiency leads to abnormalities in alpha beta T-cell development and to rapid development of T-cell lymphomas [J].

Bain, G ;

Enel, I ;

Maandag, ECR ;

teRiele, HPJ ;

Voland, JR ;

Sharp, LL ;

Chun, J ;

Huey, B ;

Pinkel, D ;

Murre, C .

MOLECULAR AND CELLULAR BIOLOGY, 1997, 17 (08) :4782-4791

[5] E2A PROTEINS ARE REQUIRED FOR PROPER B-CELL DEVELOPMENT AND INITIATION OF IMMUNOGLOBULIN GENE REARRANGEMENTS [J].

BAIN, G ;

MAANDAG, ECR ;

IZON, DJ ;

AMSEN, D ;

KRUISBEEK, AM ;

WEINTRAUB, BC ;

KROP, I ;

SCHLISSEL, MS ;

FEENEY, AJ ;

VANROON, M ;

VANDERVALK, M ;

TERIELE, HPJ ;

BERNS, A ;

MURRE, C .

CELL, 1994, 79 (05) :885-892

[6] The role of E-proteins in B- and T-lymphocyte development [J].

Bain, G ;

Murre, C .

SEMINARS IN IMMUNOLOGY, 1998, 10 (02) :143-153

[7] E2A AND E2-2 ARE SUBUNITS OF B-CELL-SPECIFIC E2-BOX DNA-BINDING PROTEINS [J].

BAIN, G ;

GRUENWALD, S ;

MURRE, C .

MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (06) :3522-3529

[8] A NOVEL B-CELL LINEAGE-SPECIFIC TRANSCRIPTION FACTOR PRESENT AT EARLY BUT NOT LATE STAGES OF DIFFERENTIATION [J].

BARBERIS, A ;

WIDENHORN, K ;

VITELLI, L ;

BUSSLINGER, M .

GENES & DEVELOPMENT, 1990, 4 (05) :849-859

[9] Functional interaction of beta-catenin with the transcription factor LEF-1 [J].

Behrens, J ;

vonKries, JP ;

Kuhl, M ;

Bruhn, L ;

Wedlich, D ;

Grosschedl, R ;

Birchmeier, W .

NATURE, 1996, 382 (6592) :638-642

[10] E47 activates the Ig-heavy chain and TdT loci in non-B cells [J].

Choi, JK ;

Shen, CP ;

Radomska, HS ;

Eckhardt, LA ;

Kadesch, T .

EMBO JOURNAL, 1996, 15 (18) :5014-5021

← 1 2 3 4 5 6 →