Effects of muscle immobilization at different lengths on tetrodotoxin-induced disuse atrophy

被引:12
作者
Dupont, AC [1 ]
Richmond, FJR
Loeb, GE
机构
[1] Univ So Calif, Alfred E Mann Inst Biomed Engn, Los Angeles, CA 90033 USA
[2] Queens Univ, Kingston, ON K7L 3N6, Canada
[3] Univ So Calif, Dept Pharm, Los Angeles, CA 90033 USA
[4] Univ So Calif, Alfred E Mann Inst Biomed Engn, Los Angeles, CA 90089 USA
关键词
atrophy; disuse; muscle length; rats;
D O I
10.1109/TNSRE.2003.817675
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Previous studies have shown that immobilization causes muscle atrophy and that the rate of atrophy depends on the length at which the muscle is immobilized. However, most studies have,been carried out in neurologically intact animals that were capable of generating at least some voluntary muscle activation. In this study, tetrodotoxin was applied chronically to the rat sciatic nerve to produce complete paralysis of distal muscles for seven days, and the ankle wag immobilized to hold the muscles at long or short lengths. Paralysis without immobilization resulted in relative weight losses of 36% for soleus, 19% for tibialis anterior (TA), and 17% for lateral gastrocnemius (LG) muscles. Casting the ankle in plantarflexion stretched TA and reduced its weight loss to 10%. Soleus and LG were shortened by this intervention and had increased losses of 43% and 28%, respectively. Fixing the limb in dorsiflexion resulted in a posture similar to that adopted by the unrestrained rats and had no significant effect on the amount of muscle atrophy compared to that in unrestrained paralyzed animals.
引用
收藏
页码:209 / 217
页数:9
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