Analysis of chromosome 18 DNA markers in multiplex pedigrees with manic depression

被引：43

作者：

Coon, H

Hoff, M

Holik, J

Hadley, D

Fang, N

Reimherr, F

Wender, P

Byerley, W

机构：

[1] Department of Psychiatry, University of Utah Medical School, Salt Lake City, UT

[2] Department of Psychiatry, University of Utah Medical School, Salt Lake City, UT 84132

来源：

BIOLOGICAL PSYCHIATRY | 1996年 / 39卷 / 08期

关键词：

manic depression; chromosome; 18; linkage analysis; LINKAGE ANALYSIS; GENETIC-LINKAGE; AFFECTIVE-DISORDERS; ILLNESS;

D O I：

10.1016/0006-3223(95)00292-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Six pedigrees segregating manic-depressive illness (MDI) were analyzed for linkage to 21 highly polymorphic microsatellite DNA markers on chromosome 18. These markers span almost the entire length of the chromosome, and gaps between markers ave less than 20 cM. In particular, we analyzed several markers localizing to the pericentromeric region of chromosome 18 which generated lod scores suggestive of linkage in an independent study. Lod score analysis was performed and results were examined by family, One region produced positive lod scores, though at 18q23 and not in the pericentromeric region. We additionally used two nonparametric methods because the true mode of transmission of MDI is unknown; results were again somewhat suggestive for markers in the region of 18q23 but not in the pericentromeric region.

引用

页码：689 / 696

页数：8

共 27 条

[1] GENETIC-LINKAGE BETWEEN X-CHROMOSOME MARKERS AND BIPOLAR AFFECTIVE-ILLNESS [J].

BARON, M ;

RISCH, N ;

HAMBURGER, R ;

MANDEL, B ;

KUSHNER, S ;

NEWMAN, M ;

DRUMER, D ;

BELMAKER, RH .

NATURE, 1987, 326 (6110) :289-292

[2] CHROMOSOME-18 DNA MARKERS AND MANIC-DEPRESSIVE ILLNESS - EVIDENCE FOR A SUSCEPTIBILITY GENE [J].

BERRETTINI, WH ;

FERRARO, TN ;

GOLDIN, LR ;

WEEKS, DE ;

DETERAWADLEIGH, S ;

NURNBERGER, JI ;

GERSHON, ES .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (13) :5918-5921

[3] DANISH TWIN STUDY OF MANIC-DEPRESSIVE DISORDERS [J].

BERTELSEN, A ;

HARVALD, B ;

HAUGE, M .

BRITISH JOURNAL OF PSYCHIATRY, 1977, 130 (APR) :330-351

[4]

Coon H., 1993, American Journal of Human Gaieties, V52, P619

[5]

*COOP HUM LINK CTR, 1994, CHLC REP

[6]

COTTINGHAM RW, 1993, AM J HUM GENET, V53, P252

[7]

DEBRUYN A, 1993, PSYCHIATR GENET, V3, P124

[8] BIPOLAR AFFECTIVE-DISORDERS LINKED TO DNA MARKERS ON CHROMOSOME-11 [J].

EGELAND, JA ;

GERHARD, DS ;

PAULS, DL ;

SUSSEX, JN ;

KIDD, KK ;

ALLEN, CR ;

HOSTETTER, AM ;

HOUSMAN, DE .

NATURE, 1987, 325 (6107) :783-787

[9]

ENDICOTT J, 1984, AM J PSYCHIAT, V136, P266

[10]

GOODWIN DW, 1984, PSYCHIATRIC DIAGNOSI, P3

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