High cardiac angiotensin-II-forming activity in infarcted and non-infarcted human myocardium

被引：36

作者：

Ihara, M

Urata, H

Shirai, K

Ideishi, M

Hoshino, F

Suzumiya, J

Kikuchi, M

Arakawa, K

机构：

[1] Fukuoka Univ, Sch Med, Dept Internal Med, Jonan Ku, Fukuoka 8140180, Japan

[2] Fukuoka Univ, Sch Med, Dept Pathol, Fukuoka 8140180, Japan

来源：

CARDIOLOGY | 2000年 / 94卷 / 04期

关键词：

angiotensin-II-forming enzyme; chymase; angiotensin-converting enzyme; mast cell; inflammatory cell; cardiac renin-angiotensin system; myocardial infarction; cardiac remodeling;

D O I：

10.1159/000047325

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The aims of this study were to compare human cardiac angiotensin-II-forming activity (AIIFA) between the intact area of control autopsy hearts without cardiac disease (n = 10) and the infarcted or non-infarcted area of autopsy hearts with myocardial infarction (MI, n = 7) and to determine responsible angiotensin-ll-forming enzymes. Cardiac total and chymase-dependent AIIFAs were significantly higher in the infarcted and non-infarcted myocardium than those in non-Mi heart, while angiotensin-converting enzyme-dependent AIIFA increased only in the infarcted myocardium, The density of chymase antibody-positive mast cells in the non-infarcted area of MI heart correlated positively with total or chymase-dependent AIIFA, Augmented AIIFA was also detected in the left atrium of post-MI hearts. Our results indicated that cardiac angiotensin II formation could be activated in the infarcted as well as in non-infarcted myocardium of the post-MI human heart, Copyright (C) 2001 S. Karger AG, Basel.

引用

页码：247 / 253

页数：7

共 25 条

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