A rapid HPLC assay for voriconazole in human plasma

被引：97

作者：

Gage, R ^{[1
]}

Stopher, DA ^{[1
]}

机构：

[1] Pfizer Cent Res, Dept Drug Metab, Sandwich, Kent, England

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1998年 / 17卷 / 08期

关键词：

voriconazole; reverse phase chromatography; protein precipitation; human plasma;

D O I：

10.1016/S0731-7085(98)00004-1

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

This report describes a simple, rapid and reproducible method with a calibration range of 0.2-10 mu g ml(-1) voriconazole in human plasma which is more appropriate for routine clinical use than the authors previously published method. The method utilises protein precipitation with acetonitrile as the only sample preparation involved prior to reverse phase HPLC. No internal standard was required. (C) 1998 Published by Elsevier Science B.V. All rights reserved.

引用

页码：1449 / 1453

页数：5

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