Enterovirus 68 among Children with Severe Acute Respiratory Infection, the Philippines

被引：111

作者：

Imamura, Tadatsugu

Fuji, Naoko

Suzuki, Akira

Tamaki, Raita ^{[2
]}

Saito, Mariko ^{[2
]}

Aniceto, Rapunzel ^{[2
,3
]}

Galang, Hazel ^{[4
]}

Sombrero, Lydia ^{[4
]}

Lupisan, Soccoro ^{[4
]}

Oshitani, Hitoshi ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Med, Dept Virol, Aoba Ku, Sendai, Miyagi 9808575, Japan

[2] Collaborating Res Ctr Emerging & Reemerging Dis, Tohoku Res Inst Trop Med, Muntinlupa, Philippines

[3] Eastern Visayas Reg Med Ctr, Tacloban City, Philippines

[4] Res Inst Trop Med, Muntinlupa, Philippines

来源：

EMERGING INFECTIOUS DISEASES | 2011年 / 17卷 / 08期

关键词：

5' NONCODING REGION; HUMAN RHINOVIRUS-87; VP1; SEQUENCE; SEROTYPE; COUNTRIES;

D O I：

10.3201/eid1708.101328

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Enterovirus 68 (EV68) is a rare enterovirus associated with respiratory illness that, unlike other enteroviruses, has been identified only from respiratory specimens. We identified EV68 from respiratory specimens of children hospitalized with a diagnosis of severe pneumonia in Leyte, Republic of the Philippines. Twenty-one samples showed high similarity with EV68 by sequencing of 5' nontranslated region; 17 of these samples were confirmed as EV68 by sequencing of viral protein 1 capsid coding region. Most previously reported EV68 cases had been identified as sporadic cases. All 21 patients we identified had severe illness, and 2 died, possibly the first reported fatal cases associated with EV68 infection. Our study suggests that EV68 may be a possible causative agent of severe respiratory illnesses.

引用

页码：1430 / 1435

页数：6

共 26 条

[1] Human rhinovirus 87 and enterovirus 68 represent a unique serotype with rhinovirus and enterovirus features [J].