Trail Making Test performance in Vietnam combat veterans with and without posttraumatic stress disorder

The present study investigated variables associated with performance on the Trail Making Test from the Halstead-Reitan neuropsychological test battery in Vietnam combat veterans. There was a significant difference in performance between veterans with and without PTSD on both parts of the Trail Making Test. In subgroup analyses excluding participants on medications (antianxiety, antidepressant, and cardiac), comorbid diagnoses (history of alcohol or substance abuse, history of major depression and comorbid anxiety disorder) and compensation-seeking status, the group difference on Trails B remained significant. However subgroup analyses suggested that poorer performance on Trails A was influenced by antianxiety and cardiac medications as well as heavy combat exposure status.