An essential role for retinoid receptors RARβ and RXRγ in long-term potentiation and depression

被引：277

作者：

Chiang, MY

Misner, D

Kempermann, G

Schikorski, T

Giguère, V

Sucov, HM

Gage, FH

Stevens, CF

Evans, RM ^{[1
]}

机构：

[1] Salk Inst Biol Studies, Howard Hughes Med Inst, Gene Express Lab, San Diego, CA 92138 USA

[2] Salk Inst Biol Studies, Howard Hughes Med Inst, Mol Neurobiol Lab, San Diego, CA 92138 USA

[3] Salk Inst Biol Studies, Genet Lab, La Jolla, CA 92037 USA

[4] McGill Univ, Dept Biochem, Mol Oncol Grp, Royal Victoria Hosp, Montreal, PQ H3A 181, Canada

[5] McGill Univ, Dept Med, Mol Oncol Grp, Royal Victoria Hosp, Montreal, PQ H3A 181, Canada

[6] McGill Univ, Dept Oncol, Mol Oncol Grp, Royal Victoria Hosp, Montreal, PQ H3A 181, Canada

[7] Univ So Calif, Sch Med, Inst Med Genet, Dept Cell & Neurobiol, Los Angeles, CA 90033 USA

来源：

NEURON | 1998年 / 21卷 / 06期

关键词：

D O I：

10.1016/S0896-6273(00)80654-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Hippocampal long-term potentiation (LTP) and longterm depression (LTD) are the most widely studied forms of synaptic plasticity thought to underlie spatial learning and memory. We report here that RAR beta deficiency in mice virtually eliminates hippocampal CA1 LTP and LTD. It also results in substantial performance deficits in spatial learning and memory tasks. Surprisingly, RXR gamma null mice exhibit a distinct phenotype in which LTD is lost whereas LTP is normal. Thus, while retinoid receptors contribute to both LTP and LTD, they do so in different ways. These findings not only genetically uncouple LTP and LTD but also reveal a novel and unexpected role for vitamin A in higher cognitive functions.

引用

页码：1353 / 1361

页数：9

共 58 条

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