Lower brain-derived neurotrophic factor in serum of relapsing remitting MS: Reversal by glatiramer acetate

被引：157

作者：

Azoulay, D

Vachapova, V

Shihman, B

Miler, A

Karni, A

机构：

[1] Tel Aviv Univ, Sackler Fac Med, Tel Aviv Sourasky Med Ctr, Dept Neurol, IL-64239 Tel Aviv, Israel

[2] Technion Israel Inst Technol, Rappaport Fac Med, Carmel Med Ctr, Neuroimmunol Unit, Haifa, Israel

[3] Technion Israel Inst Technol, Rappaport Fac Med, Carmel Med Ctr, Res Unit, Haifa, Israel

[4] Technion Israel Inst Technol, Res Inst, Haifa, Israel

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2005年 / 167卷 / 1-2期

关键词：

multiple sclerosis; neuroprotection; brain-derived neurotrophic factor; glatiramer acetate;

D O I：

10.1016/j.jneuroim.2005.07.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Neuronal growth factors may exert a neuroprotective effect in multiple sclerosis (MS). We found reduced levels of brain-derived neurotrophic factors (BDNF) in the serum and CSF of relapsing-remitting MS patients, which was reversed by therapy with glatiramer acetate. BDNF may play a protective role in MS, and immunomodulation therapy, such as with glatiramer acetate, may enhance the action this mechanism. (C) 2005 Elsevier B.V. All rights reserved.

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页码：215 / 218

页数：4

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