Humanized mice for the development and testing of human vaccines

被引：4

作者：

Aspord, Caroline ^{[1
]}

Yu, Chun I.

Banchereau, Jacques

Palucka, A. Karolina

机构：

[1] Baylor Inst Immunol Res, Dallas, TX 75204 USA

来源：

EXPERT OPINION ON DRUG DISCOVERY | 2007年 / 2卷 / 07期

基金：

美国国家卫生研究院;

关键词：

CD34; HPC; humanized mice; immune system; immunotherapy; vaccine;

D O I：

10.1517/17460441.2.7.949

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Mouse models of human disease form a link between genetics and biology. However, mice and humans differ in many aspects of immune system biology. These differences might explain, in part, why many successful preclinical immunotherapy studies in mice turn out to be unsuccessful when used in clinical trials in humans. Pioneering studies in the late 1980s demonstrated the reconstitution of human lympho-hematopoietic cells in immunodeficient mice. Since this time, imnnunodeficient mice are being tested as hosts for human hematopoietic organs or cells in an effort to create an in vivo model of the complete human immune system. Such Humouse models could permit us to generate and test novel human vaccines.

引用

收藏

页码：949 / 960

页数：12

相关论文

共 82 条

[1] Co-expression of HLA DR3 and DQ8 results in the development of spontaneous insulitis and loss of tolerance to GAD65 in transgenic mice [J].

Abraham, RS ;

Kudva, YC ;

Wilson, SB ;

Strominger, JL ;

David, CS .

DIABETES, 2000, 49 (04) :548-554

[2] Breast cancer instructs dendritic cells to prime interleukin 13-secreting CD4+ T cells that facilitate tumor development [J].

Aspord, Caroline ;

Pedroza-Gonzalez, Alexander ;

Gallegos, Mike ;

Tindle, Sasha ;

Burton, Elizabeth C. ;

Su, Dan ;

Marches, Florentina ;

Banchereau, Jacques ;

Palucka, A. Karolina .

JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (05) :1037-1047

[3] Disseminated and sustained HIV infection in CD34+ cord blood cell-transplanted Rag2-/-γc-/- mice [J].

Baenziger, Stefan ;

Tussiwand, Roxane ;

Schlaepfer, Erika ;

Mazzucchelli, Luca ;

Heikenwalder, Mathias ;

Kurrer, Michael O. ;

Behnke, Silvia ;

Frey, Joachim ;

Oxenius, Annette ;

Joller, Helen ;

Aguzzi, Adriano ;

Manz, Markus G. ;

Speck, Roberto F. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (43) :15951-15956

[4] Dendritic cells and the control of immunity [J].

Banchereau, J ;

Steinman, RM .

NATURE, 1998, 392 (6673) :245-252

[5] Human-SCID mouse chimeric models for the evaluation of anti-cancer therapies [J].

Bankert, RB ;

Egilmez, NK ;

Hess, SD .

TRENDS IN IMMUNOLOGY, 2001, 22 (07) :386-393

[6] Rejection of human islets and human HLA-A2.1 transgenic mouse islets by alloreactive human lymphocytes in immunodeficient NOD-scid and NOD-Rag1nullPrf1null mice [J].

Banuelos, SJ ;

Shultz, LD ;

Greiner, DL ;

Burzenski, LM ;

Gott, B ;

Lyons, BL ;

Rossini, AA ;

Appel, MC .

CLINICAL IMMUNOLOGY, 2004, 112 (03) :273-283

[7] Dengue fever in humanized NOD/SCID mice [J].

Bente, DA ;

Melkus, MW ;

Garcia, JV ;

Rico-Hesse, R .

JOURNAL OF VIROLOGY, 2005, 79 (21) :13797-13799

[8] A SEVERE COMBINED IMMUNODEFICIENCY MUTATION IN THE MOUSE [J].

BOSMA, GC ;

CUSTER, RP ;

BOSMA, MJ .

NATURE, 1983, 301 (5900) :527-530

[9] Identification of protective Lassa virus epitopes that are restricted by HLA-A2 [J].

Botten, Jason ;

Alexander, Jeff ;

Pasquetto, Valerie ;

Sidney, John ;

Barrowman, Polly ;

Ting, Joey ;

Peters, Bjoern ;

Southwood, Scott ;

Stewart, Barbara ;

Rodriguez-Carreno, Maria P. ;

Mothe, Bianca ;

Whitton, J. Lindsay ;

Sette, Alessandro ;

Buchmeier, Michael J. .

JOURNAL OF VIROLOGY, 2006, 80 (17) :8351-8361

[10] CD1: Antigen presentation and T cell function [J].

Brigl, M ;

Brenner, MB .

ANNUAL REVIEW OF IMMUNOLOGY, 2004, 22 :817-890

← 1 2 3 4 5 6 7 8 9 →