Vancomycin stress response in a sensitive and a tolerant strain of Streptococcus pneumoniae

被引：49

作者：

Haas, W

Kaushal, D

Sublett, J

Obert, C

Tuomanen, EI

机构：

[1] St Jude Childrens Res Hosp, Dept Infect Dis, Memphis, TN USA

[2] St Jude Childrens Res Hosp, Dept Funct Genom, Memphis, TN USA

[3] St Jude Childrens Res Hosp, Hartwell Ctr Bioinformat & Biotechnol, Memphis, TN USA

来源：

JOURNAL OF BACTERIOLOGY | 2005年 / 187卷 / 23期

关键词：

D O I：

10.1128/JB.187.23.8205-8210.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The vancomycin stress response was studied in Streptococcus pneumoniae strains T4 (TIGR4) and Tupelo. Vancomycin affected the expression of 175 genes, including genes encoding transport functions and enzymes involved in aminosugar metabolism. The two-component systems TCS03, TCS11, and CiaRH also responded to antibiotic treatment. We hypothesize that the three regulons are an important part of the bacterium's response to vancomycin stress.

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收藏

页码：8205 / 8210

页数：6

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