Psychiatric genetics gets a boost

被引：21

作者：

Maher, Brion S. ^{[1
,2
,3
]}

Riley, Brien P. ^{[1
,2
,3
]}

Kendler, Kenneth S. ^{[1
,2
,3
]}

机构：

[1] Virginia Commonwealth Univ, Sch Med, Virginia Inst Psychiat & Behav Genet, Richmond, VA 23298 USA

[2] Virginia Commonwealth Univ, Sch Med, Dept Psychiat, Richmond, VA 23298 USA

[3] Virginia Commonwealth Univ, Sch Med, Dept Human & Mol Genet, Richmond, VA 23298 USA

来源：

NATURE GENETICS | 2008年 / 40卷 / 09期

关键词：

D O I：

10.1038/ng0908-1042

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Defining the molecular nature of the genetic risk of psychiatric disorders has been notoriously difficult. Now, a flurry of genome-wide association studies for schizophrenia and bipolar disorder provides preliminary evidence for replicated signals.

引用

页码：1042 / 1044

页数：3

共 17 条

[1]

Bassett AS, 2000, AM J MED GENET, V97, P45, DOI 10.1002/(SICI)1096-8628(200021)97:1<45::AID-AJMG6>3.0.CO

[2]

2-9

[3] Genomics - When the smoke clears ... [J].

Chanock, Stephen J. ;

Hunter, David J. .

NATURE, 2008, 452 (7187) :537-538

[4] Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder [J].

Ferreira, Manuel A. R. ;

O'Donovan, Michael C. ;

Meng, Yan A. ;

Jones, Ian R. ;

Ruderfer, Douglas M. ;

Jones, Lisa ;

Fan, Jinbo ;

Kirov, George ;

Perlis, Roy H. ;

Green, Elaine K. ;

Smoller, Jordan W. ;

Grozeva, Detelina ;

Stone, Jennifer ;

Nikolov, Ivan ;

Chambert, Kimberly ;

Hamshere, Marian L. ;

Nimgaonkar, Vishwajit L. ;

Moskvina, Valentina ;

Thase, Michael E. ;

Caesar, Sian ;

Sachs, Gary S. ;

Franklin, Jennifer ;

Gordon-Smith, Katherine ;

Ardlie, Kristin G. ;

Gabriel, Stacey B. ;

Fraser, Christine ;

Blumenstiel, Brendan ;

Defelice, Matthew ;

Breen, Gerome ;

Gill, Michael ;

Morris, Derek W. ;

Elkin, Amanda ;

Muir, Walter J. ;

McGhee, Kevin A. ;

Williamson, Richard ;

MacIntyre, Donald J. ;

MacLean, Alan W. ;

Clair, David St ;

Robinson, Michelle ;

Van Beck, Margaret ;

Pereira, Ana C. P. ;

Kandaswamy, Radhika ;

McQuillin, Andrew ;

Collier, David A. ;

Bass, Nicholas J. ;

Young, Allan H. ;

Lawrence, Jacob ;

Ferrier, I. Nicol ;

Anjorin, Adebayo ;

Farmer, Anne .

NATURE GENETICS, 2008, 40 (09) :1056-1058

[5] The 'Common Disease-Common Variant' Hypothesis and Familial Risks [J].

Hemminki, Kari ;

Foersti, Asta ;

Bermejo, Justo Lorenzo .

PLOS ONE, 2008, 3 (06)

[6]

*INT SCHIZ CONS, 2008, NATURE 0730

[7] Heterogeneity in Meta-Analyses of Genome-Wide Association Investigations [J].

Ioannidis, John P. A. ;

Patsopoulos, Nikolaos A. ;

Evangelou, Evangelos .

PLOS ONE, 2007, 2 (09)

[8] THE GENETICS OF SCHIZOPHRENIA - A CURRENT, GENETIC-EPIDEMIOLOGIC PERSPECTIVE [J].

KENDLER, KS ;

DIEHL, SR .

SCHIZOPHRENIA BULLETIN, 1993, 19 (02) :261-285

[9] Identification of loci associated with schizophrenia by genome-wide association and follow-up [J].

O'Donovan, Michael C. ;

Craddock, Nicholas ;

Norton, Nadine ;

Williams, Hywel ;

Peirce, Timothy ;

Moskvina, Valentina ;

Nikolov, Ivan ;

Hamshere, Marian ;

Carroll, Liam ;

Georgieva, Lyudmila ;

Dwyer, Sarah ;

Holmans, Peter ;

Marchini, Jonathan L. ;

Spencer, Chris C. A. ;

Howie, Bryan ;

Leung, Hin-Tak ;

Hartmann, Annette M. ;

Moeller, Hans-Juergen ;

Morris, Derek W. ;

Shi, YongYong ;

Feng, GuoYin ;

Hoffmann, Per ;

Propping, Peter ;

Vasilescu, Catalina ;

Maier, Wolfgang ;

Rietschel, Marcella ;

Zammit, Stanley ;

Schumacher, Johannes ;

Quinn, Emma M. ;

Schulze, Thomas G. ;

Williams, Nigel M. ;

Giegling, Ina ;

Iwata, Nakao ;

Ikeda, Masashi ;

Darvasi, Ariel ;

Shifman, Sagiv ;

He, Lin ;

Duan, Jubao ;

Sanders, Alan R. ;

Levinson, Douglas F. ;

Gejman, Pablo V. ;

Cichon, Sven ;

Noethen, Markus M. ;

Gill, Michael ;

Corvin, Aiden ;

Rujescu, Dan ;

Kirov, George ;

Owen, Michael J. .

NATURE GENETICS, 2008, 40 (09) :1053-1055

[10] On the allelic spectrum of human disease [J].

Reich, DE ;

Lander, ES .

TRENDS IN GENETICS, 2001, 17 (09) :502-510

← 1 2 →