Quantitative culture of Chlamydia trachomatis:: Relationship of inclusion-forming units produced in culture to clinical manifestations and acute inflammation in urogenital disease

被引:43
作者
Geisler, WM [1 ]
Suchland, RJ [1 ]
Whittington, WLH [1 ]
Stamm, WE [1 ]
机构
[1] Univ Washington, Sch Med, Div Allergy & Infect Dis, Seattle, WA 98195 USA
关键词
D O I
10.1086/323998
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The relationship of Chlamydia trachomatis inclusion-forming units in quantitative culture to clinical manifestations and inflammation in urogenital disease was assessed in 1179 patients attending a sexually transmitted diseases clinic. In women, greater inclusion-forming unit counts were associated with cervical mucopus (3000 vs. 450 ifu), amount and character of cervical discharge, greater than or equal to 30 polymorphonuclear cells (PMNL) per high-power field (hpf) on Gram stain (2050 vs. 320 ifu), and diagnoses of mucopurulent cervicitis (MPC; 2550 vs. 300 ifu) and pelvic inflammatory disease (PID; 3000 vs. 578 ifu). In men, greater inclusion-forming unit counts were associated with urethral discharge (85 vs. 44 ifu), amount and character of discharge, and greater than or equal to 10 PMNL/hpf (95 vs. 50 ifu). These associations persisted on multivariate analysis. Thus, chlamydial replication is associated with MPC and PID in women, urethritis in men, and inflammation in both. Since infections with high inclusion counts may be the most transmissible, identification and treatment of patients with these chlamydia-associated syndromes is important in control programs.
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收藏
页码:1350 / 1354
页数:5
相关论文
共 10 条
[1]   QUANTITATIVE CULTURE OF ENDOCERVICAL CHLAMYDIA-TRACHOMATIS [J].
BARNES, RC ;
KATZ, BP ;
ROLFS, RT ;
BATTEIGER, B ;
CAINE, V ;
JONES, RB .
JOURNAL OF CLINICAL MICROBIOLOGY, 1990, 28 (04) :774-780
[2]   Quantitative Chlamydia trachomatis cultures:: Correlation of chlamydial inclusion-forming units with serovar, age, sex, and race [J].
Eckert, LO ;
Suchland, RJ ;
Hawes, SE ;
Stamm, WE .
JOURNAL OF INFECTIOUS DISEASES, 2000, 182 (02) :540-544
[3]   Epidemiology and clinical manifestations of unique Chlamydia trachomatis isolates that occupy nonfusogenic inclusions [J].
Geisler, WM ;
Suchland, RJ ;
Rockey, DD ;
Stamm, WE .
JOURNAL OF INFECTIOUS DISEASES, 2001, 184 (07) :879-884
[4]  
HOBSON D, 1980, BRIT J VENER DIS, V56, P156
[5]   NUCLEOTIDE-SEQUENCE OF THE VARIABLE DOMAINS WITHIN THE MAJOR OUTER-MEMBRANE PROTEIN GENE FROM SEROVARIANTS OF CHLAMYDIA-TRACHOMATIS [J].
LAMPE, MF ;
SUCHLAND, RJ ;
STAMM, WE .
INFECTION AND IMMUNITY, 1993, 61 (01) :213-219
[6]  
MALLINSON H, 1982, BRIT J VENER DIS, V58, P36
[7]  
SCHACHTER J, 1999, SEXUALLY TRANSMITTED, P398
[8]   Isolates of Chlamydia trachomatis that occupy nonfusogenic inclusions lack IncA, a protein localized to the inclusion membrane [J].
Suchland, RJ ;
Rockey, DD ;
Bannantine, JP ;
Stamm, WE .
INFECTION AND IMMUNITY, 2000, 68 (01) :360-367
[9]   3 NEW SEROVARS OF CHLAMYDIA-TRACHOMATIS - DA, IA, AND L2A [J].
WANG, SP ;
GRAYSTON, JT .
JOURNAL OF INFECTIOUS DISEASES, 1991, 163 (02) :403-405
[10]   NUCLEOTIDE AND DEDUCED AMINO-ACID SEQUENCES FOR THE 4 VARIABLE DOMAINS OF THE MAJOR OUTER-MEMBRANE PROTEINS OF THE 15 CHLAMYDIA-TRACHOMATIS SEROVARS [J].
YUAN, Y ;
ZHANG, YX ;
WATKINS, NG ;
CALDWELL, HD .
INFECTION AND IMMUNITY, 1989, 57 (04) :1040-1049