Rapid eye movement sleep behavior disorder and potassium channel antibody-associated limbic encephalitis

被引：152

作者：

Iranzo, A

Graus, F

Clover, L

Morera, J

Bruna, J

Vilar, C

Martínez-Rodriguez, JE

Vincent, A

Santamaría, J

机构：

[1] Hosp Clin Barcelona, Serv Neurol, E-08036 Barcelona, Spain

[2] Inst Invest Biomed August Pi Sunyer, Barcelona, Spain

[3] John Radcliffe Hosp, Weatherall Inst Mol Med, Neurosci Grp, Oxford OX3 9DU, England

[4] Hosp Alicante, Serv Neurol, Alicante, Spain

[5] Hosp Univ Bellvitge, Neurol Serv, Lhospitalet De Llobregat, Spain

[6] Hosp Gen Castello, Serv Neurol, Castellon de La Plana, Spain

来源：

ANNALS OF NEUROLOGY | 2006年 / 59卷 / 01期

关键词：

D O I：

10.1002/ana.20693

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Of six patients registered in our center with nonparaneoplastic limbic encephalitis associated with antibodies to voltage-gated potassium channels, the five men had rapid eye movement sleep behavior disorder (RBD) coincident with voltage-gated potassium channel antibody-associated limbic encephalitis onset. In three patients, immunosuppression resulted in resolution of RBD in parallel with remission of the limbic syndrome. RBD persisted in two patients with partial resolution of the limbic syndrome. Our findings suggest that RBD is frequent in the setting of voltage-gated potassium channel antibody-associated limbic encephalitis and can be related to autoimmune-mediated mechanisms. In addition, these observations suggest that impairment of the limbic system may play a role in the pathogenesis of RBD.

引用

页码：178 / 182

页数：5

共 20 条

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