Expression of CD3ε, CD3ζ, and RAG-1/RAG-2 in decidual CD56+ NK cells

被引：15

作者：

King, A ^{[1
]}

Gardner, L ^{[1
]}

Sharkey, A ^{[1
]}

Loke, YW ^{[1
]}

机构：

[1] Univ Cambridge, Dept Pathol, Res Grp Human Reprod Immunobiol, Cambridge CB2 1QP, England

来源：

CELLULAR IMMUNOLOGY | 1998年 / 183卷 / 02期

基金：

英国惠康基金;

关键词：

D O I：

10.1006/cimm.1998.1250

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In early pregnancy the uterine mucosa, the decidua, is infiltrated by numerous CD56(bright), CD16(-) natural killer (NK) cells. In this paper we have shown that unlike adult peripheral blood NK cells these uterine NK cells express cytoplasmic CD3 and CD3 zeta, but CD3 gamma and CD3 delta were not found in the majority of cells. In contrast to previous reports, there was no evidence of RAG-1 nor RAG-2 expression in decidual NK cells. These findings have implications for the ontogeny and development of decidual NK cells. (C) 1998 Academic Press.

引用

页码：99 / 105

页数：7

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