The tetrameric structure of a glutamate receptor channel

被引：606

作者：

Rosenmund, C

Stern-Bach, Y

Stevens, CF ^{[1
]}

机构：

[1] Salk Inst, Howard Hughes Med Inst, La Jolla, CA 92093 USA

[2] Max Planck Inst Biophys Chem, Workgrp Cellular Neurobiol, Gottingen, Germany

[3] Hebrew Univ Jerusalem, Haddassah Dent Sch, Dept Anat & Embryol, Jerusalem, Israel

来源：

SCIENCE | 1998年 / 280卷 / 5369期

关键词：

D O I：

10.1126/science.280.5369.1596

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The subunit stoichiometry of several ligand-gated ion channel receptors is still unknown. A counting method was developed to determine the number of subunits in one family of brain glutamate receptors, Successful application of this method in an HEK cell line provides evidence that ionotropic glutamate receptors share a tetrameric structure with the voltage-gated potassium channels. The average conductance of these channels depends on how many subunits are occupied by an agonist.

引用

页码：1596 / 1599

页数：4

共 35 条

[1] KINETIC-ANALYSIS OF ANTAGONIST ACTION AT N-METHYL-D-ASPARTIC ACID RECEPTORS - 2 BINDING-SITES EACH FOR GLUTAMATE AND GLYCINE [J].