BCL-2 but not its Epstein-Barr virus-encoded homologue, BHRF1, is commonly expressed in posttransplantation lymphoproliferative disorder

被引:77
作者
Murray, PG
Swinnen, LJ
Constandinou, CM
Pyle, JM
Carr, TJ
Hardwick, JM
Ambinder, RF
机构
[1] JOHNS HOPKINS ONCOL CTR,BALTIMORE,MD 21231
[2] JOHNS HOPKINS UNIV,SCH MED,DEPT PHARMACOL & MOLEC SCI,BALTIMORE,MD 21205
[3] LOYOLA UNIV CHICAGO,MAYWOOD,IL
关键词
D O I
10.1182/blood.V87.2.706.bloodjournal872706
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Posttransplantation lymphoproliferative disease (PTLD) is virtually always associated with Epstein-Barr virus (EBV) infection. BCL-2 and other proteins that confer resistance to apoptosis have been implicated in the pathogenesis of a variety of malignancies including lymphomas. One EBV protein, BHRF1, is a homologue of BCL-5, whereas another, the latency membrane protein 1 (LMP-1), upregulates BCL-2 expression in vitro. In the present study, we used immunohistochemistry to study the expression of these viral and cellular proteins as well as a variety of other EBV-encoded proteins in PTLD. BHRF1 was not detected in any PTLD specimen, whereas BCL-5 was shown in 12 of 17 lesions examined. With one exception, all LMP1-positive cases also expressed BCL-2 and the absence of LMP1 was always associated with a lack of BCL-2 expression. The results do not support a role for the EBV homologue of BCL-2 in PTLD, but they do support a role for viral induction of BCL-2 expression. (C) 1996 by The American Society of Hematology.
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页码:706 / 711
页数:6
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