Nuclear factor-κB inhibitors as sensitizers to anticancer drugs

被引：675

作者：

Nakanishi, C ^{[1
]}

Toi, M ^{[1
]}

机构：

[1] Komagome Hosp, Tokyo Metropolitan Canc & Infect Dis Ctr, Bunkyo Ku, Tokyo 1138677, Japan

来源：

NATURE REVIEWS CANCER | 2005年 / 5卷 / 04期

关键词：

D O I：

10.1038/nrc1588

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The cytotoxicity of chemotherapeutic agents is attributed to apoptosis. Acquired resistance to the effects of chemotherapy has emerged as a significant impediment to effective cancer therapy. One feature that cytotoxic treatments of cancer have in common is their activation of the transcription factor nuclear factor-kappa B (NF-kappa B), which regulates cell survival. NF-kappa B activation suppresses the apoptotic potential of chemotherapeutic agents and contributes to resistance. What evidence is there that inhibitors of NF-kappa B might promote apoptosis in cancer cells and can NF-kappa B inhibitors be used to overcome resistance to chemotherapeutic agents?

引用

页码：297 / 309

页数：13

共 138 条

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