Synthesis and Anti-Helicobacter pylori Activity of 4-(Coumarin-3-yl)thiazol-2-ylhydrazone Derivatives

被引：36

作者：

Chimenti, Franco ^{[1
]}

Bizzarri, Bruna ^{[1
]}

Bolasco, Adriana ^{[1
]}

Secci, Daniela ^{[1
]}

Chimenti, Paola ^{[1
]}

Granese, Arianna ^{[1
]}

Carradori, Simone ^{[1
]}

D'Ascenzio, Melissa ^{[1
]}

Scaltrito, M. Maddalena ^{[2
]}

Sisto, Francesca ^{[2
]}

机构：

[1] Univ Roma La Sapienza, Dipartimento Chim & Tecnol Farmaco, I-00185 Rome, Italy

[2] Univ Milan, Dipartimento Sanita Pubbl Microbiol Virol, I-20133 Milan, Italy

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2010年 / 47卷 / 06期

关键词：

ONE-STEP SYNTHESIS; BIOLOGICAL-ACTIVITY; IN-VITRO; COUMARINS; AGENTS;

D O I：

10.1002/jhet.464

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学];

摘要：

A novel class of coumarin-thiazole conjugated systems (1-31) were synthesized by Hantzsch condensation between alpha-bromo-3-acetyl coumarin and several thiosemicarbazone intermediates. This scaffold was also evaluated for selective antibacterial activity against 20 isolates of H. pylori clinical strains, including four metronidazole resistant ones.

引用

页码：1269 / 1274

页数：6

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