A pH-Responsive Host-guest Nanosystem Loading Succinobucol Suppresses Lung Metastasis of Breast Cancer

被引：64

作者：

Dan, Zhaoling ^{[1
,2
,3
]}

Cao, Haiqiang ^{[1
,2
]}

He, Xinyu ^{[1
,2
]}

Zhang, Zhiwen ^{[1
,2
]}

Zou, Lili ^{[3
]}

Zeng, Lijuan ^{[4
]}

Xu, Yan ^{[3
]}

Yin, Qi ^{[1
,2
]}

Xu, Minghua ^{[1
,2
]}

Zhong, Dafang ^{[1
,2
]}

Yu, Haijun ^{[1
,2
]}

Shen, Qi ^{[3
]}

Zhang, Pengcheng ^{[1
,2
]}

Li, Yaping ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China

[3] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China

[4] Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China

来源：

THERANOSTICS | 2016年 / 6卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Host-guest nanosystem; pH-responsive; Cyclodextrin; Cancer metastasis; Breast cancer; MESOPOROUS SILICA NANOPARTICLES; DRUG-DELIVERY; GENE DELIVERY; CYCLODEXTRIN; THERAPY; DOXORUBICIN; SYSTEMS; TUMORS; VCAM-1; SIRNA;

D O I：

10.7150/thno.13896

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Cancer metastasis is the leading reason for the high mortality of breast cancer. Herein, we report on a pH-responsive host-guest nanosystem of succinobucol (PHN) with pH-stimuli controlled drug release behavior to improve the therapeutic efficacy on lung metastasis of breast cancer. PHN was composed of the host polymer of beta-cyclodextrin linked with multiple arms of N,N-diisopropylethylenediamine (beta CD-DPA), the guest polymer of adamantyl end-capped methoxy poly(ethylene glycol) (mPEG-Ad), and the active agent of succinobucol. PHN comprises nanometer-sized homogenous spherical particles, and exhibits specific and rapid drug release in response to the intracellular acidic pH-stimuli. Then, the anti-metastatic efficacy of PHN is measured in metastatic 4T1 breast cancer cells, which effectively confirms the superior inhibitory effects on cell migration and invasion activities, VCAM-1 expression and cell-cell binding of RAW 264.7 to 4T1 cells. Moreover, PHN can be specifically delivered to the sites of metastatic nodules in lungs, and result in an obviously improved therapeutic efficacy on lung metastasis of breast cancer. Thereby, the pH-responsive host-guest nanosystem can be a promising drug delivery platform for effective treatment of cancer metastasis.

引用

页码：435 / 445

页数：11

共 44 条

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