Comparisons of intraocular-pressure-lowering efficacy and side effects of 2% dorzolamide and 1 % brinzolamide

Forty-one healthy volunteers were recruited for a study to compare the intraocular pressure (IOP)-lowering efficacy and side effects of 2% dorzolamide and 1% brinzolamide. In a randomized double-blind design, one eye received one drop of 2% dorzolamide and the other eye received one drop of 1% brinzolamide, The IOP and side effects were evaluated by Goldmann applanation tonometry and slit lamp biomicroscopy before administration, and 3, 7 and 14 days after the initial administration of eyedrops, The IOP decreased significantly from baseline for both drugs (p < 0.05), However, there were no statistically significant differences between 2% dorzolamide and 1% brinzolamide either before or after eyedrop administration (p > 0.05), The most frequent side effect was ocular pain in the case of 2% dorzolamide and blurred vision in 1% brinzolamide, The results suggested that 2% dorzolamide and 1% brinzolamide have similar IOP-lowering efficacies with different side effects Copyright (C) 2001 S.Karger AG, Basel.