Reduced antioxidant defense in early onset first-episode psychosis: a case-control study

被引：88

作者：

Antonio Mico, Juan ^{[2
]}

Olga Rojas-Corrales, Maria ^{[2
]}

Gibert-Rahola, Juan ^{[2
]}

Parellada, Mara ^{[3
]}

Moreno, Dolores ^{[3
]}

Fraguas, David

Graell, Montserrat ^{[4
]}

Gil, Javier ^{[5
]}

Irazusta, Jon ^{[5
]}

Castro-Fornieles, Josefina ^{[6
]}

Soutullo, Cesar ^{[7
]}

Arango, Celso ^{[3
]}

Otero, Soraya ^{[8
]}

Navarro, Ana ^{[9
]}

Baeza, Inmaculada

Martinez-Cengotitabengoa, Monica ^{[9
]}

Gonzalez-Pinto, Ana ^{[1
]}

机构：

[1] Univ Basque Country, Ctr Invest Biomed Red Salud Mental, CIBERSAM, Dept Psychiat,Hosp Santiago, Vitoria, Spain

[2] Univ Cadiz, Ctr Invest Biomed Red Salud Mental, CIBERSAM, Dept Neurosci Pharmacol & Psychiat,Sch Med, Vitoria, Spain

[3] Hosp Gen Univ Gregorio Maranon, Ctr Invest Biomed Red Salud Mental, CIBERSAM, Dept Psychiat,Adolescent Unit, Madrid, Spain

[4] Hosp Infantil Univ Nino Jesus, Sect Child & Adolescent Psychiat & Psychol, Madrid, Spain

[5] Univ Basque Country, Fac Med & Dent, Dept Physiol, Bilbao, Bizkaia, Spain

[6] Hosp Clin Univ Barcelona, Ctr Invest Biomed Red Salud Mental, Dept Child & Adolescent Psychiat & Psychol, CIBERSAM,IDIBAPS,Inst Clin Neurosci, Barcelona, Spain

[7] Univ Navarra, Child & Adolescent Psychiat Unit, Dept Psychiat & Med Psychol, E-31080 Pamplona, Spain

[8] Valdecilla Univ Hosp, Dept Psychiat, Child & Adolescent Psychiat Unit, Santander, Cantabria, Spain

[9] Univ Cadiz, Ctr Invest Biomed Red Salud Mental, CIBERSAM, Dept Biochem & Mol Biol,Sch Med, Cadiz, Spain

来源：

BMC PSYCHIATRY | 2011年 / 11卷

关键词：

DEVELOPMENTAL INFANTILE PSYCHOSIS; AGE-CHILDREN-PRESENT; K-SADS-PL; OXIDATIVE STRESS; SUPEROXIDE-DISMUTASE; GLUTATHIONE DEFICIT; AFFECTIVE-DISORDERS; LIPID-PEROXIDATION; BIPOLAR DISORDER; ATYPICAL ANTIPSYCHOTICS;

D O I：

10.1186/1471-244X-11-26

中图分类号：

R749 [精神病学];

学科分类号：

100204 [神经病学];

摘要：

Background: Our objective is to determine the activity of the antioxidant defense system at admission in patients with early onset first psychotic episodes compared with a control group. Methods: Total antioxidant status (TAS) and lipid peroxidation (LOOH) were determined in plasma. Enzyme activities and total glutathione levels were determined in erythrocytes in 102 children and adolescents with a first psychotic episode and 98 healthy controls. Results: A decrease in antioxidant defense was found in patients, measured as decreased TAS and glutathione levels. Lipid damage (LOOH) and glutathione peroxidase activity was higher in patients than controls. Our study shows a decrease in the antioxidant defense system in early onset first episode psychotic patients. Conclusions: Glutathione deficit seems to be implicated in psychosis, and may be an important indirect biomarker of oxidative stress in early-onset schizophrenia. Oxidative damage is present in these patients, and may contribute to its pathophysiology.

引用

页数：8

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