A dermal HOX transcriptional program regulates site-specific epidermal fate

被引：167

作者：

Rinn, John L. ^{[1
]}

Wang, Jordon K. ^{[1
,2
]}

Allen, Nancy ^{[3
]}

Brugmann, Samantha A. ^{[3
]}

Mikels, Amanda J. ^{[2
,5
]}

Liu, Helen ^{[1
]}

Ridky, Todd W. ^{[1
]}

Stadler, H. Scott ^{[6
]}

Nusse, Roel ^{[4
,5
]}

Helms, Jill A. ^{[3
]}

Chang, Howard Y. ^{[1
,2
]}

机构：

[1] Stanford Univ, Sch Med, Program Epithelial Biol, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Canc Biol Program, Stanford, CA 94305 USA

[3] Stanford Univ, Sch Med, Dept Surg, Stanford, CA 94305 USA

[4] Stanford Univ, Sch Med, Howard Hughes Med Inst, Stanford, CA 94305 USA

[5] Stanford Univ, Sch Med, Dept Dev Biol, Stanford, CA 94305 USA

[6] Shriners Hosp Children, Div Res, Portland, OR 97239 USA

来源：

GENES & DEVELOPMENT | 2008年 / 22卷 / 03期

关键词：

HOXA13; WNT5A; chromatin immunoprecipitation; gene regulation; epithelial-mesenchymal interaction;

D O I：

10.1101/gad.1610508

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

Reciprocal epithelial-mesenchymal interactions shape site-specific development of skin. Here we show that site-specific HOX expression in fibroblasts is cell-autonomous and epigenetically maintained. The distal-specific gene HOXA13 is continually required to maintain the distal-specific transcriptional program in adult fibroblasts, including expression of WNT5A, a morphogen required for distal development. The ability of distal fibroblasts to induce epidermal keratin 9, a distal-specific gene, is abrogated by depletion of HOXA13, but rescued by addition of WNT5A. Thus, maintenance of appropriate HOX transcriptional program in adult fibroblasts may serve as a source of positional memory to differentially pattern the epithelia during homeostasis and regeneration.

引用

页码：303 / 307

页数：5

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