Effect of gamma-hydroxybutyric acid on human platelet aggregation in vitro

被引：14

作者：

Franconi, F

Miceli, M

Alberti, L

Boatto, G

Coinu, R

De Montis, MG

Tagliamonte, A

机构：

[1] Univ Siena, Inst Pharmacol, I-53100 Siena, Italy

[2] Univ Sassari, Dept Chem Chem, I-07100 Sassari, Italy

[3] Annunziata Hosp, Clin Lab, Florence, Italy

[4] Univ Sassari, Dept Pharmacol, I-07100 Sassari, Italy

来源：

THROMBOSIS RESEARCH | 2001年 / 102卷 / 03期

关键词：

D O I：

10.1016/S0049-3848(01)00249-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

GHB reduced platelent aggregability induced by collagen and AA in a dose-dependent way. When AA is the trigger of aggregation, it was more potent than aspirin. Moreover, it reduced the second wave of ADP aggregation and thrombin-triggered aggregation. Nevertheless, it was ineffective on aggregation stimulated by the agonist of Tx receptors. The GHB inhibitory effect is accomplished by a decrease in Tx production and it is prevented by NMDS antagonists.

引用

页码：255 / 260

页数：6

共 18 条

[1] PLATELET ACTIVATION [J].