Polo and Aurora kinases - lessons derived from chemical biology

被引：112

作者：

Taylor, Stephen ^{[1
]}

Peters, Jan-Michael ^{[2
]}

机构：

[1] Univ Manchester, Fac Life Sci, Manchester M13 PT, Lancs, England

[2] Res Inst Mol Pathol, A-1030 Vienna, Austria

来源：

CURRENT OPINION IN CELL BIOLOGY | 2008年 / 20卷 / 01期

关键词：

D O I：

10.1016/j.ceb.2007.11.008

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

During the cell division cycle, mitotic entry, spindle assembly, chromosome segregation, and cytokinesis must all be carefully coordinated to ensure that the two daughter cells inherit all the genetic material required for further growth and development. Central to this coordination are several protein kinases including Aurora A, Aurora B, and the Polo-like kinase, Plk1. A number of small-molecule Aurora and Plk1 inhibitors have been developed because these kinases are seen as attractive anticancer drug targets. These inhibitors are now being widely used as chemical biology tools to understand how these kinases ensure faithful genome transmission.

引用

页码：77 / 84

页数：8

共 53 条

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