SEPT9_V1 protein expression is associated with human cancer cell resistance to microtubule disrupting agents

被引：37

作者：

Arnir, Sharon ^{[1
]}

Mabjeesh, Nicola J. ^{[1
]}

机构：

[1] Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Dept Urol, Prostate Canc Res Lab, IL-64239 Tel Aviv, Israel

来源：

CANCER BIOLOGY & THERAPY | 2007年 / 6卷 / 12期

关键词：

HIF; SEPT9; 2-methoxyestradiol; paclitaxel; cancer; microtubules; septins;

D O I：

10.4161/cbt.6.12.4971

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

SEPT9 is a mammalian septin family member. There is growing evidence that SEPT9 plays a role in cancer. The protein product, SEPT9_V1, associates with microtubules and interacts with hypoxia-inducible factor (HIF)-1 alpha, the regulated subunit of the key transcription factor HIF-1. HIF-1 transcriptional activity is thoroughly dependent on intact microtubules. We tested the hypothesis that SEPT9_V1 confers resistance to microtubule-mediated HIF-1 inhibitors. SEPT9_V1 protein expression was strongly correlated with susceptibility of a wide range of cancer cells to 2-methoxyestradiol and paclitaxel. Our results revealed that SEPT9_V1 could serve as a biomarker for therapeutic resistance to microtubule disrupting agents.

引用

收藏

页码：1926 / 1931

页数：6

相关论文

共 39 条

[1] MSF-A interacts with hypoxia-inducible factor-1α and augments hypoxia-inducible factor transcriptional activation to affect tumorigenicity and angiogenesis [J].

Amir, S ;

Wang, RX ;

Matzkin, H ;

Simons, JW ;

Mabjeesh, NJ .

CANCER RESEARCH, 2006, 66 (02) :856-866

[2] Altered expression of the septin gene, SEPT9, in ovarian neoplasia [J].

Burrows, JF ;

Chanduloy, S ;

McIlhatton, MA ;

Nagar, H ;

Yeates, K ;

Donaghy, P ;

Price, J ;

Godwin, AK ;

Johnston, PG ;

Russell, SHE .

JOURNAL OF PATHOLOGY, 2003, 201 (04) :581-588

[3] SEPT2 is a new fusion partner of MLL in acute myeloid leukemia with t(2;11)(q37;q23) [J].

Cerveira, N. ;

Correia, C. ;

Bizarro, S. ;

Pinto, C. ;

Lisboa, S. ;

Mariz, J. M. ;

Marques, M. ;

Teixeira, M. R. .

ONCOGENE, 2006, 25 (45) :6147-6152

[4] Inhibitory effect of YC-1 on the hypoxic induction of erythropoietin and vascular endothelial growth factor in Hep3B cells [J].

Chun, YS ;

Yeo, EJ ;

Choi, E ;

Teng, CM ;

Bae, JM ;

Kim, MS ;

Park, JW .

BIOCHEMICAL PHARMACOLOGY, 2001, 61 (08) :947-954

[5] Both microtubule-stabilizing and microtubule-destabilizing drugs inhibit hypoxia-inducible factor-1α accumulation and activity by disrupting microtubule function [J].

Escuin, D ;

Kline, ER ;

Giannakakou, P .

CANCER RESEARCH, 2005, 65 (19) :9021-9028

[6] Hypoxia-inducible factors: central regulators of the tumor phenotype [J].

Gordan, John D. ;

Simon, M. Celeste .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2007, 17 (01) :71-77

[7] Expression profiling the human septin gene family [J].

Hall, PA ;

Jung, K ;

Hillan, KJ ;

Russell, SEH .

JOURNAL OF PATHOLOGY, 2005, 206 (03) :269-278

[8] The pathobiology of the septin gene family [J].

Hall, PA ;

Russell, SEH .

JOURNAL OF PATHOLOGY, 2004, 204 (04) :489-505

[9] Regulation of angiogenesis by hypoxia-inducible factor 1 [J].

Hirota, Kiichi ;

Semenza, Gregg L. .

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2006, 59 (01) :15-26

[10] Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1α-degradative pathway [J].

Isaacs, JS ;

Jung, YJ ;

Mimnaugh, EG ;

Martinez, A ;

Cuttitta, F ;

Neckers, LM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (33) :29936-29944

← 1 2 3 4 →