prICE: A downstream target for ceramide-induced apoptosis and for the inhibitory action Bcl-2

被引：195

作者：

Smyth, MJ

Perry, DK

Zhang, JD

Poirier, GG

Hannun, YA

Obeid, LM

机构：

[1] DUKE UNIV,MED CTR,DEPT MED,DURHAM,NC 27710

[2] DUKE UNIV,MED CTR,DIV GERIATR,DURHAM,NC 27710

[3] DEPT VET AFFAIRS MED CTR,CTR GERIATR RES EDUC & CLIN,DURHAM,NC

[4] DUKE UNIV,MED CTR,DIV HEMATOL ONCOL,DURHAM,NC 27710

[5] DUKE UNIV,DEPT CELL BIOL,DURHAM,NC 27710

[6] CHU LAVAL,RES CTR,MOLEC ENDOCRINOL LAB,POLYADP RIBOSE METAB GRP,QUEBEC CITY,PQ G1V 4G2,CANADA

[7] UNIV LAVAL,QUEBEC CITY,PQ G1V 4G2,CANADA

来源：

BIOCHEMICAL JOURNAL | 1996年 / 316卷

关键词：

D O I：

10.1042/bj3160025

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The novel lipid second messenger, ceramide, specifically induced poly(ADP-ribose) polymerase cleavage through activation of the protease prICE. Over-expression of Bcl-2 inhibited ceramide-induced poly(ADP-ribose) polymerase proteolysis and protected cells from ceramide-induced death. These data provide the first insight into the mechanism by which ceramide mediates apoptosis and suggest a mechanism by which Bcl-2 protects from cell death.

引用

页码：25 / 28

页数：4

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