A quarter century of granzymes

被引：138

作者：

Ewen, C. L. ^{[1
,2
]}

Kane, K. P. ^{[2
]}

Bleackley, R. C. ^{[1
]}

机构：

[1] Univ Alberta, Dept Biochem, Edmonton, AB T6G 2H7, Canada

[2] Univ Alberta, Dept Med Microbiol & Immunol, Edmonton, AB T6G 2H7, Canada

来源：

CELL DEATH AND DIFFERENTIATION | 2012年 / 19卷 / 01期

基金：

加拿大健康研究院;

关键词：

granzymes; apoptosis; cytotoxic T cells; NK cells; LYMPHOCYTE PROTEASE GRANZYME; CYTOCHROME-C RELEASE; CTL-MEDIATED APOPTOSIS; INDEPENDENT CELL-DEATH; B-INDUCED APOPTOSIS; DNA FRAGMENTATION; NATURAL-KILLER; CASPASE ACTIVATION; SERINE PROTEASES; DIRECT CLEAVAGE;

D O I：

10.1038/cdd.2011.153

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Granzymes (Grs) were discovered just over a quarter century ago. They are produced by cytotoxic T cells and natural killer cells and are released upon interaction with target cells. Intensive biochemical, genetic, and biological studies have been performed in order to study their roles in immunity and inflammation. This review summarizes research on the family of Grs. Cell Death and Differentiation (2012) 19, 28-35; doi:10.1038/cdd.2011.153; published online 4 November 2011

引用

页码：28 / 35

页数：8

共 107 条

[1]

Molecular ordering of the caspase activation cascade initiated by the cytotoxic T lymphocyte/natural killer (CTL/NK) protease granzyme B [J].

Adrain, C ;

Murphy, BM ;

Martin, SJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (06) :4663-4673

[2]

Granzyme B directly and efficiently cleaves several downstream caspase substrates: Implications for CTL-induced apoptosis [J].

Andrade, F ;

Roy, S ;

Nicholson, D ;

Thornberry, N ;

Rosen, A ;

Casciola-Rosen, L .

IMMUNITY, 1998, 8 (04) :451-460

[3]

Granzyme H destroys the function of critical adenoviral proteins required for viral DNA replication and granzyme B inhibition [J].

Andrade, Felipe ;

Fellows, Edward ;

Jenne, Dieter E. ;

Rosen, Antony ;

Young, C. S. H. .

EMBO JOURNAL, 2007, 26 (08) :2148-2157

[4]

Cytotoxic T lymphocyte-assisted suicide - Caspase 3 activation is primarily the result of the direct action of granzyme B [J].

Atkinson, EA ;

Barry, M ;

Darmon, AJ ;

Shostak, I ;

Turner, PC ;

Moyer, RW ;

Bleackley, RC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (33) :21261-21266

[5]

Granzyme B short-circuits the need for caspase 8 activity during granule-mediated cytotoxic T-lymphocyte killing by directly cleaving bid [J].

Barry, M ;

Heibein, JA ;

Pinkoski, MJ ;

Lee, SF ;

Moyer, RW ;

Green, DR ;

Bleackley, RC .

MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (11) :3781-3794

[6]

Intracellular versus extracellular granzyme B in immunity and disease: challenging the dogma [J].

Boivin, Wendy Anne ;

Cooper, Dawn Michelle ;

Hiebert, Paul Ryan ;

Granville, David James .

LABORATORY INVESTIGATION, 2009, 89 (11) :1195-1220

[7]

CTL secretory lysosomes: biogenesis and secretion of a harmful organelle [J].

Bossi, G ;

Griffiths, GM .

SEMINARS IN IMMUNOLOGY, 2005, 17 (01) :87-94

[8]

NK cell protease granzyme M targets α-tubulin and disorganizes the microtubule network [J].

Bovenschen, Niels ;

de Koning, Pieter J. A. ;

Quadir, Razi ;

Broekhuizen, Roel ;

Damen, J. Mirjam A. ;

Froelich, Christopher J. ;

Slijper, Monique ;

Kummer, J. Alain .

JOURNAL OF IMMUNOLOGY, 2008, 180 (12) :8184-8191

[9]

THE INDUCIBLE CYTOTOXIC LYMPHOCYTE-T-ASSOCIATED GENE TRANSCRIPT CTLA-1 SEQUENCE AND GENE LOCALIZATION TO MOUSE CHROMOSOME-14 [J].

BRUNET, JF ;

DOSSETO, M ;

DENIZOT, F ;

MATTEI, MG ;

CLARK, WR ;

HAQQI, TM ;

FERRIER, P ;

NABHOLZ, M ;

SCHMITTVERHULST, AM ;

LUCIANI, MF ;

GOLSTEIN, P .

NATURE, 1986, 322 (6076) :268-271

[10]

Antihemostatic activity of human granzyme B mediated by cleavage of von Willebrand factor [J].

Buzza, Marguerite S. ;

Dyson, Jennifer M. ;

Choi, Hiuwan ;

Gardiner, Elizabeth E. ;

Andrews, Robert K. ;

Kaiserman, Dion ;

Mitchell, Christina A. ;

Berndt, Michael C. ;

Dong, Jing-Fei ;

Bird, Phillip I. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (33) :22498-22504

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