B-vitamins reduce plasma levels of beta amyloid

被引：35

作者：

Flicker, Leon ^{[1
]}

Martins, Ralph N. ^{[2
]}

Thomas, Jenny ^{[1
]}

Acres, John ^{[1
,3
]}

Taddei, Kevin ^{[2
]}

Vasikaran, Samuel D. ^{[4
]}

Norman, Paul ^{[5
]}

Jamrozik, Konrad ^{[6
]}

Almeida, Osvaldo P. ^{[3
]}

机构：

[1] Univ Western Australia, Sch Med & Pharmacol, Nedlands, WA 6009, Australia

[2] Edith Cowan Univ, Churchlands, WA 6018, Australia

[3] Univ Western Australia, Sch Psychiat & Clin Neurosci, Nedlands, WA 6009, Australia

[4] Royal Perth Hosp, Dept Core Clin Pathol & Biochem, Perth, WA, Australia

[5] Univ Western Australia, Sch Surg & Pathol, Nedlands, WA 6009, Australia

[6] Univ Queensland, Sch Populat Hlth, St Lucia, Qld 4067, Australia

来源：

NEUROBIOLOGY OF AGING | 2008年 / 29卷 / 02期

基金：

英国医学研究理事会;

关键词：

Alzheimer; B vitamins; amyloid beta protein;

D O I：

10.1016/j.neurobiolaging.2006.10.007

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Elevated plasma homocysteine (tHcy) is a risk factor for Alzheimer's disease (AD), and thus B vitamins may have a role in the prevention of AD. The objective of this study was to determine if tHcy lowering vitamins decrease the circulating levels of A-beta protein 1-40 (A beta 40). We randomized 299 older men to treatment with 2 mg of folate, plus 25 mg of B6 and 400 mu g of B 12, or placebo. After 2 years of treatment the mean (S.E.) increase of A beta 40 was 7.0pg/ml (8.4) in the vitamin group (4.9%), and 26.8pg/ml (7.7) (18.5%) in the placebo group. We conclude that B vitamins may decrease the plasma level of A beta 40 and have a role in the prevention of AD. (C) 2006 Elsevier Inc. All rights reserved.

引用

页码：303 / 305

页数：3

共 7 条

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