Correlation between β2-glycoprotein antibodies and antiphospholipid antibodies in patients with reproductive failure

被引:10
作者
Chong, P
Matzner, W
Ching, W
机构
[1] Reprod Immunol Associates, Van Nuys, CA 91405 USA
[2] Sepulveda Vet Adm Med Ctr, N Hills, CA USA
来源
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 1998年 / 40卷 / 06期
关键词
antiphospholipid antibodies; cardiolipin antibodies; beta(2); glycoprotein antibodies; reproductive failure; failed IVFs;
D O I
10.1111/j.1600-0897.1998.tb00427.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
PROBLEM: Antiphospholipid antibodies (APAs) are important in the etiology of reproductive failure. Studies have shown that binding proteins are necessary for the detection of APAs. One of these, beta(2)-glycoprotein, has been shown to be necessary for detection of anticardiolipin antibodies. It is felt that some APAs may be directed to the binding protein itself, or to a combination of the binding protein and phospholipid. METHOD OF STUDY: In this study, a comparison of APAs vs. anti beta(2)-glycoprotein antibodies was performed on the sera of 123 women younger than 40 years of age with a history of reproductive failure. Antibodies to six phospholipid epitopes, cardiolipin, phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol, phosphatidic acid, phosphatidylglycerol, and phosphatidylserine, were measured. RESULTS: Of the 123 women tested, 33 had one or more positive immunoglobulin (Ig)G antibodies to phospholipids, of which 9 were to cardiolipin. However, only 1 of 123 women had IgG antibodies to beta(2)-glycoprotein and she was APA negative. Thirty-eight of 123 women had one or more IgM antibodies to phospholipids, with none directed to cardiolipin IgM. In contrast, only 8 of the 123 women had IgM antibodies to beta(2)-glycoprotein. Five of the eight patients had IgM APA; 4 of 5 had IgM antibodies to PE, 1 to PI. CONCLUSIONS: There is no correlation between Pz-glycoprotein antibodies and APA status in this population. To date, our most sensitive test for detecting phospholipid autoimmune-mediated in vitro fertilization failure still appears to be the ELISA assay for APA.
引用
收藏
页码:414 / 417
页数:4
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