A comparative study of mist and bubble column reactors in the in vitro production of artemisinin

被引:44
作者
Kim, Y
Wyslouzil, BE
Weathers, PJ
机构
[1] Worcester Polytech Inst, Dept Biol & Biotechnol, Worcester, MA 01609 USA
[2] Worcester Polytech Inst, Dept Chem Engn, Worcester, MA 01609 USA
基金
美国国家科学基金会; 美国国家卫生研究院;
关键词
Artemisia annua; artemisinin; hairy roots; bubble column reactor; nutrient mist reactor;
D O I
10.1007/s002990100342
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Artemisia annua hairy roots grown in nutrient mist reactors produced nearly three times as much artemisinin as roots grown in bubble column reactors, 2.64 mug/g DW and 0.98 mug/g DW respectively.
引用
收藏
页码:451 / 455
页数:5
相关论文
共 17 条
[1]   PRODUCTION OF INDOLE ALKALOIDS BY SELECTED HAIRY ROOT LINES OF CATHARANTHUS-ROSEUS [J].
BHADRA, R ;
VANI, S ;
SHANKS, JV .
BIOTECHNOLOGY AND BIOENGINEERING, 1993, 41 (05) :581-592
[2]  
Ferreira J. F. S., 1997, Horticultural Reviews, V19, P319
[3]  
Gamborg O. L., 1968, EXP CELL RES, V50, P148
[4]  
HILTON MG, 1990, APPL MICROBIOL BIOT, V33, P132, DOI 10.1007/BF00176513
[5]   USE OF GENETIC-TRANSFORMATION BY THE RI T-DNA OF AGROBACTERIUM-RHIZOGENES TO STIMULATE BIOMASS AND TROPANE ALKALOID PRODUCTION IN ATROPA-BELLADONNA AND CALYSTEGIA-SEPIUM ROOTS GROWN-INVITRO [J].
JUNG, G ;
TEPFER, D .
PLANT SCIENCE, 1987, 50 (02) :145-151
[6]   Production of artemisinin by shoot cultures of Artemisia annua L. in a modified inner-loop mist bioreactor [J].
Liu, CZ ;
Wang, YC ;
Guo, C ;
Ouyang, F ;
Ye, HC ;
Li, GF .
PLANT SCIENCE, 1998, 135 (02) :211-217
[7]  
MCKELVEY SA, 1993, BIOTECHNOL PROGR, V9, P371
[8]   Artemisinin and the antimalarial endoperoxides: From herbal remedy to targeted chemotherapy [J].
Meshnick, SR ;
Taylor, TE ;
Kamchonwongpaisan, S .
MICROBIOLOGICAL REVIEWS, 1996, 60 (02) :301-+
[9]  
NUUTILA AM, 1994, BIOTECHNOL TECH, V8, P61, DOI 10.1007/BF00207635
[10]   BIOREACTORS FOR GROWTH OF PLANT-ROOTS [J].
RODRIGUEZMENDIOLA, MA ;
STAFFORD, A ;
CRESSWELL, R ;
ARIASCASTRO, C .
ENZYME AND MICROBIAL TECHNOLOGY, 1991, 13 (09) :697-702