A novel bridged stilbenoid trimer and four highly condensed stilbenoid oligomers in Vatica rassak

被引：74

作者：

Ito, T

Tanaka, T

Nakaya, K

Iinuma, M

Takahashi, Y

Naganawa, H

Ohyama, M

Nakanishi, Y

Bastow, KF

Lee, KH

机构：

[1] Gifu Prefectural Inst Hlth & Environm Sci, Gifu 5040838, Japan

[2] Gifu Pharmaceut Univ, Gifu 5025858, Japan

[3] Inst Microbial Chem, Shinagawa Ku, Tokyo 1410021, Japan

[4] Univ N Carolina, Sch Pharm, Nat Prod Lab, Chapel Hill, NC 27599 USA

来源：

TETRAHEDRON | 2001年 / 57卷 / 34期

关键词：

natural product; resveratrol; hexamer; heptamer; Dipterocarpaceae; cytotoxicity;

D O I：

10.1016/S0040-4020(01)00697-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

Vaticanol G (1) and vaticaside D (2) isolated from stem bark of Vatica rassak (Dipterocarpaceae) were the first instance of stilbenoid trimers with an unusual tribenzobicyclo[3.3.2]decatriene system. Vaticanols D (3) and H (4)-J (6) were elucidated to be a stilbenoid hexamer or heptamer containing a structurally identical trimeric unit. Their structures and the relative configurations were established on the basis of 2D NMR spectroscopy. The hexamers (3, 4 and 5) and the heptemer (6) showed cytotoxicity against KB cells. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：7309 / 7321

页数：13

共 48 条

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CANALICULATOL, AN ANTIFUNGAL RESVERATROL TRIMER FROM STEMONOPOROUS-CANALICULATUS [J].