Reduced health-related quality of life among Hodgkin's disease survivors: A comparative study with general population norms

被引:62
作者
Loge, JH
Abrahamsen, AF
Ekeberg, O
Kaasa, S
机构
[1] Univ Oslo, Dept Behav Sci Med, N-0317 Oslo, Norway
[2] Univ Oslo, Norwegian Radium Hosp, N-0317 Oslo, Norway
[3] Univ Trondheim Hosp, Dept Radiotherapy & Oncol, Palliat Med Unit, Trondheim, Norway
[4] Norwegian Univ Sci & Technol, Unit Appl Clin Res, N-7034 Trondheim, Norway
关键词
health related quality of life; Hodgkin's disease; normative data; questionnaires (SF-36);
D O I
10.1023/A:1008315525997
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background. Late complications after curative treatment of Hodgkin's disease are of special relevance because most of the cured are young adults. The aims of the present study were: (1) to compare health-related quality of life (HRQOL) in Hodgkin's disease (HD) survivors with normative data from the general Norwegian population and (2) to examine the relations between disease/treatment characteristics and HRQOL in the HD survivors. Patients and methods: 459 HD survivors aged 19-74 years (mean 44.0, SD 11.8) treated at the Norwegian Radium Hospital 1971-1991 were approached in 1994 and compared to norms from 2214 subjects approached in 1996. The norms are representative of the general Norwegian population. HRQOL was assessed by the Short Form 36 (SF-36), which measures HRQOL in eight separate scales (0 = worst health state, 100 = best health state). Results. The HD survivors had lower scores than the normal controls on all scales after adjustment for age, gender and educational levels. Statistically significant differences (P < 0.01) were found in general health (10.4), physical functioning (6.1), role limitations (physical, 9.3), social functioning (3.6) and in vitality (4.7). Patients with disease stage IB-IIB had the lowest scores on all scales. The differences in relation to stage/substage reached statistical significance (P < 0.01) in physical functioning and in role limitations (physical). Time since diagnosis, types of primary treatment or having relapsed were not associated with statistically significant differences in HRQOL. Conclusion: Long-term HD survivors have poorer HRQOL, primarily in physical health, than the general Norwegian population.
引用
收藏
页码:71 / 77
页数:7
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