Developmental changes of gene expression in heme metabolic enzymes in rat placenta

被引：26

作者：

Ihara, N

Akagi, R

Ejiri, K

Kudo, T

Furuyama, K

Fujita, H

机构：

[1] Okayama Prefectural Univ, Fac Hlth & Welf Sci, Dept Nutr Sci, Soja 7191197, Japan

[2] Tohoku Univ, Sch Med, Dept Mol Biol, Aoba Ku, Sendai, Miyagi 9800872, Japan

[3] Tohoku Univ, Sch Med, Dept Biochem, Aoba Ku, Sendai, Miyagi 9800872, Japan

[4] Okayama Univ, Sch Med, Dept Obstet & Gynecol, Okayama 7000914, Japan

来源：

FEBS LETTERS | 1998年 / 439卷 / 1-2期

关键词：

placenta; trophoblast; fetus; heme; delta-aminolevulinate synthase; heme oxygenase; hypoxia;

D O I：

10.1016/S0014-5793(98)01324-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transcription levels of the non-specific delta-aminolevulinate synthase (ALAS-N) and heme oxygenase-1 (HO-1) in the placenta at the terminal stage of pregnancy mere comparable to those in the female adult liver and in the spleen, respectively. Immunohistochemical studies demonstrated that both enzymes mere exclusively expressed in the trophoblast. During gestation, transcript of ALAS-N slightly increased, while HO-1 mRNA significantly decreased. Induced acute fetal hypoxia resulted in an increase in ALAS-N mRNA and in a decrease in HO-1 mRNA. These findings indicate that placental heme metabolism is influenced by the oxygen supply. (C) 1998 Federation of European Biochemical Societies.

引用

页码：163 / 167

页数：5

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