Heparanase, galectin-3, and tissue factor mRNA are expressed in benign neoplasms of the thyroid

被引：5

作者：

Buchs, AE

Zehavi, S

Sher, O

Yeheskely, E

Muggia-Sulam, M

Sherman, Y

Rapoport, MJ

机构：

[1] Tel Aviv Univ, Assaf Harofeh Med Ctr, Diabet Unit, Zerifin, Israel

[2] Tel Aviv Univ, Assaf Harofeh Med Ctr, Dept Pathol, Zerifin, Israel

[3] Tel Aviv Univ, Assaf Harofeh Med Ctr, Dept Ear Nose & Throat, Zerifin, Israel

[4] Hadassah Univ Hosp, Dept Surg, IL-91120 Jerusalem, Israel

[5] Hadassah Univ Hosp, Dept Pathol, IL-91120 Jerusalem, Israel

来源：

ENDOCRINE | 2003年 / 22卷 / 02期

关键词：

galectin-3; heparanase; tissue factor; thyroid neoplasms;

D O I：

10.1385/ENDO:22:2:81

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: Heparanase, galectin-3, and tissue factor (TF) are overexpressed in solid malignant thyroid tumors. We studied their expression in multinodular goiters (MNGs). Design and Methods: Thyroid tissue specimens from 15 MNGs were obtained during surgery. mRNA expression for galectin-3, heparanase, and TF was assessed by RT-PCR. Results: Isolated expressions of heparanase and galectin-3 mRNA were expressed in 2 and 4 of the 15 MNGs, respectively; 8/15 MNGs were positive for both heparanase and galectin-3. TF mRNA was found in all MNG specimens. Conclusion: Galectin-3, heparanase, and TF RNA expression is prevalent in MNGs. Further studies will be needed to determine the prognostic significance of these findings.

引用

页码：81 / 83

页数：3

共 21 条

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