Interleukin-1 beta activates PI 3-kinase in renal mesangial cells

被引：9

作者：

Donaldson, A

DaphnaIken, D

Tetsuka, T

Morrison, AR

机构：

[1] WASHINGTON UNIV,SCH MED,DEPT MOL BIOL & PHARMACOL,ST LOUIS,MO 63110

[2] WASHINGTON UNIV,SCH MED,DEPT MED,ST LOUIS,MO 63110

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1996年 / 227卷 / 01期

关键词：

D O I：

10.1006/bbrc.1996.1502

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interleukin-1 beta rapidly stimulates the activation of phosphatidylinositol 3-hydroxyl kinase in renal mesangial cells. This intedeukin-1 beta dependent activation is associated with a rapid increase in phosphatidyl inositol 3,4,5 phosphate in renal mesangial cells. The increase in PI 3-kinase activity is inhibited by wortmannin. In addition wortmannin partially inhibited IL-1 beta induced PGE(2) production and potentiated IL-1 beta induced nitric oxide production. These experiments suggest that IL-IP can activate PI 3-kinase in renal mesangial cells and that the enzyme plays a role in IL-1 beta induced PGE(2) and NO formation in the renal mesangial cell. (C) 1996 Academic Press, Inc.

引用

收藏

页码：289 / 293

页数：5

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