Longins: a new evolutionary conserved VAMP family sharing a novel SNARE domain

被引:91
作者
Filippini, F
Rossi, V
Galli, T
Budillon, A
D'Urso, M
D'Esposito, M
机构
[1] Univ Padua, Dept Biol, Mol Biol & Bioinformat Unit, I-35100 Padua, Italy
[2] Inst Curie, INSERM, Grp Membrane Traff & Neuronal Plast, U536, F-75005 Paris, France
[3] Inst Curie, CNRS, UMR 144, F-75005 Paris, France
[4] CNR, Int Inst Genet & Biophys, Genome Res & Sequencing Lab, I-80125 Naples, Italy
关键词
D O I
10.1016/S0968-0004(01)01861-8
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
This article describes the discovery of a novel SNARE domain that might be involved in the regulation of membrane fusion, This domain is shared by a novel family of VAMPs called long VAMPs or longins. Members of this family are more conserved among eukaryotes than are classical VAMPs, possibly because of their underlying basic SNARE function.
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收藏
页码:407 / 409
页数:3
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