12-Hydroxyeicosatetraenoic acid upregulates P-selectin-induced tissue factor activity on monocytes

被引：28

作者：

Pellegrini, G

Malandra, R

Celi, A

Furie, BC

Furie, B

Lorenzet, R

机构：

[1] Ist Ric Farmacol Mario Negri, Consorzio Mario Negri Sud, Dept Vasc Med & Pharmacol, Antonio Taticchi Unit Atherosclerosis & Thrombosi, I-66030 Santa Maria Imbaro, Italy

[2] Univ Pisa, UO Fisiopatol Resp, Dipartimento Cardiol Angiol & Pneumol, Pisa, Italy

[3] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Ctr Hemostasis & Thrombosis Res, Boston, MA 02111 USA

来源：

FEBS LETTERS | 1998年 / 441卷 / 03期

关键词：

tissue factor; P-selectin; 12-hydroxyeicosatetraenoic acid; monocyte;

D O I：

10.1016/S0014-5793(98)01610-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

12-Hydroxyeicosatetraenoic acid (12-HETE), a product of the platelet lipoxygenase pathway, amplifies tissue factor expression by P-selectin-stimulated monocytes in a time- and dose-dependent fashion. The same effect is observed when monocytes are incubated with Chinese hamster ovary transfected with the P-selectin cDNA. Both 5-HETE and leukotriene C-4 are inactive in this system, Furthermore, the effect is not dependent on non-specific monocyte adhesion, since monocytes incubated with CHO cells expressing E-selectin do not express tissue factor, either in the presence or in the absence of 12-HETE. These results show that 12-HETE is a cofactor for the expression of tissue factor by monocytes. (C) 1998 Federation of European Biochemical Societies.

引用

页码：463 / 466

页数：4

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