Mitochondrial cytochrome c release may occur by volume-dependent mechanisms not involving permeability transition

被引：48

作者：

Gogvadze, V

Robertson, JD

Enoksson, M

Zhivotovsky, B

Orrenius, S

机构：

[1] Karolinska Inst, Inst Environm Med, Div Toxicol, SE-17177 Stockholm, Sweden

[2] Inst Theoret & Expt Biophys, Pushchino 142290, Russia

来源：

BIOCHEMICAL JOURNAL | 2004年 / 378卷

关键词：

apoptosis; cytochrome c; mitochondria; permeability transition; swelling; valinomycin;

D O I：

10.1042/BJ20031193

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mechanisms regulating mitochondrial outer-membrane permeabilization and the release of cytochrome c during apoptosis remain controversial. In the present study, we show in an in vitro model system that the release of cytochrome c may occur via moderate modulation of mitochondrial volume, irrespective of the mechanism leading to the mitochondrial swelling. In contrast with mitochondrial permeability transition-dependent release of cytochrome c, in the present study mitochondria remain intact and functionally active.

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收藏

页码：213 / 217

页数：5

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