Heparin-induced thrombocytopenia in neurologic disease treated with unfractionated heparin

被引：30

作者：

Harbrecht, U

Bastians, B

Kredteck, A

Hanfland, P

Klockgether, T

Pohl, C

机构：

[1] Univ Bonn, Inst Expt Haematol & Transfus Med, D-53105 Bonn, Germany

[2] Univ Bonn, Dept Neurol, D-53105 Bonn, Germany

来源：

NEUROLOGY | 2004年 / 62卷 / 04期

关键词：

D O I：

10.1212/01.WNL.0000110187.16764.9A

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The risk for immune-mediated heparin-induced thrombocytopenia (HIT) in neurologic patients receiving unfractionated heparin (UFH) is not known. In a prospective study of 200 patients, the authors found a 2.5% rate of HIT and a 2% rate of HIT-associated thromboses, suggesting that neurologic patients treated with UFH are at considerable risk for development of HIT and its complications. Prevalence of heparin-induced antibodies was 20.5% and was dependent on heparin dose. It was higher in cerebrovascular than in noncerebrovascular (29.4% versus 11.2%, p<0.01) patients.

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页码：657 / 659

页数：3

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