Diabetes and fragility fractures - A burgeoning epidemic?

被引：41

作者：

Epstein, Sol ^{[1
]}

LeRoith, Derek ^{[1
]}

机构：

[1] Mt Sinai Sch Med, Dept Endocrinol Diabet & Bone Dis, New York, NY 10029 USA

来源：

BONE | 2008年 / 43卷 / 01期

关键词：

diabetes; osteoporosis; fragility fractures; neuropathy thiazolidinediones; insulin; obesity; IGF-1;

D O I：

10.1016/j.bone.2008.03.017

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Diabetes and osteoporosis are both diseases of epidemic proportions whose incidence is increasing worldwide. The etiology of osteoporosis is multifactorial and may differ for type 1(T1DM) as compared to type 2 (T2DM). Fragility fractures are common to both types of diabetes with hip fractures occurring more frequently in the elderly T2DM population. The use of oral PPAR gamma agonists in the treatment of T2DM has also added to the risk of fracture. This perspective discusses the etiologies and issues relating to the association of diabetes with osteoporosis and fractures and suggests some theories to clarify the underlying pathophysiology. Unfortunately at this time treatment for osteoporosis and fractures remains empirical. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：3 / 6

页数：4

共 42 条

[1] Insulin receptor substrate-2 maintains predominance of anabolic function over catabolic function of osteoblasts [J].

Akune, T ;

Ogata, N ;

Hoshi, K ;

Kubota, N ;

Terauchi, Y ;

Tobe, K ;

Takagi, H ;

Azuma, Y ;

Kadowaki, T ;

Nakamura, K ;

Kawaguchi, H .

JOURNAL OF CELL BIOLOGY, 2002, 159 (01) :147-156

[2] Osteoporosis in the Cohen diabetic rat: Correlation between histomorphometric changes in bone and microangiopathy [J].

Amir, G ;

Rosenmann, E ;

Sherman, Y ;

Greenfeld, Z ;

Ne'eman, Z ;

Cohen, AM .

LABORATORY INVESTIGATION, 2002, 82 (10) :1399-1405

[3] Vitamin D, glucose tolerance and insulinaemia in elderly men [J].

Baynes, KCR ;

Boucher, BJ ;

Feskens, EJM ;

Kromhout, D .

DIABETOLOGIA, 1997, 40 (03) :344-347

[4] Generation of a new congenic mouse strain to test the relationships among serum insulin-like growth factor I, bone mineral density, and skeletal morphology in vivo [J].

Bouxsein, ML ;

Rosen, CJ ;

Turner, CH ;

Ackert, CL ;

Shultz, KL ;

Donahue, LR ;

Churchill, G ;

Adamo, ML ;

Powell, DR ;

Turner, RT ;

Müller, R ;

Beamer, WG .

JOURNAL OF BONE AND MINERAL RESEARCH, 2002, 17 (04) :570-579

[5] Insulin-like growth factor-binding protein-1 expression in cultured human bone cells: Regulation by insulin and glucocorticoid [J].

Conover, CA ;

Lee, PDK ;

Riggs, BL ;

Powell, DR .

ENDOCRINOLOGY, 1996, 137 (08) :3295-3301

[6] Functional inactivation, of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes [J].

Fernández, AM ;

Kim, JK ;

Yakar, S ;

Dupont, J ;

Hernandez-Sanchez, C ;

Castle, AL ;

Filmore, J ;

Shulman, GI ;

Le Roith, D .

GENES & DEVELOPMENT, 2001, 15 (15) :1926-1934

[7]

FRITTON JC, 2007, SLENDER LONG BONE SK

[8]

*GLOB PREV DIAB, 2004, DIABETES CARE, V27, P1047

[9] DIMINISHED BONE-FORMATION IN EXPERIMENTAL DIABETES - RELATIONSHIP TO OSTEOID MATURATION AND MINERALIZATION [J].

GOODMAN, WG ;

HORI, MT .

DIABETES, 1984, 33 (09) :825-831

[10]

Gunczler P, 1998, J PEDIATR ENDOCR MET, V11, P413

← 1 2 3 4 5 →