Coast-to-Coast Spread of SARS-CoV-2 during the Early Epidemic in the United States

被引：214

作者：

Fauver, Joseph R. ^{[1
]}

Petrone, Mary E. ^{[1
]}

Hodcroft, Emma B. ^{[2
,3
]}

Shioda, Kayoko ^{[1
]}

Ehrlich, Hanna Y. ^{[1
]}

Watts, Alexander G. ^{[4
]}

Vogels, Chantal B. F. ^{[1
]}

Brito, Anderson F. ^{[1
]}

Alpert, Tara ^{[5
]}

Muyombwe, Anthony ^{[6
]}

Razeq, Jafar ^{[6
]}

Downing, Randy ^{[6
]}

Cheemarla, Nagarjuna R. ^{[7
]}

Wyllie, Anne L. ^{[1
]}

Kalinich, Chaney C. ^{[1
]}

Ott, Isabel M. ^{[8
]}

Quick, Joshua ^{[9
]}

Loman, Nicholas J. ^{[9
]}

Neugebauer, Karla M. ^{[5
]}

Greninger, Alexander L. ^{[10
,11
]}

Jerome, Keith R. ^{[10
,11
]}

Roychoudhury, Pavitra ^{[10
,11
]}

Xie, Hong ^{[10
]}

Shrestha, Lasata ^{[10
]}

Huang, Meei-Li ^{[10
,11
]}

Pitzer, Virginia E. ^{[1
]}

Iwasaki, Akiko ^{[12
,13
]}

Omer, Saad B. ^{[1
,14
,15
,16
]}

Khan, Kamran ^{[4
,17
,18
]}

Bogoch, Isaac I. ^{[18
]}

Martinello, Richard A. ^{[15
,19
,20
]}

Foxman, Ellen F. ^{[7
,12
]}

Landry, Marie L. ^{[7
,15
,21
]}

Neher, Richard A. ^{[2
,3
]}

Ko, Albert, I ^{[1
]}

Grubaugh, Nathan D. ^{[1
]}

机构：

[1] Yale Sch Publ Hlth, Dept Epidemiol Microbial Dis, New Haven, CT 06510 USA

[2] Univ Basel, Biozentrum, CH-4056 Basel, Switzerland

[3] Swiss Inst Bioinformat, CH-1015 Lausanne, Switzerland

[4] BlueDot, Toronto, ON M5J 1A7, Canada

[5] Yale Univ, Dept Mol Biophys & Biochem, POB 6666, New Haven, CT 06510 USA

[6] Connecticut State Dept Publ Hlth, Hartford, CT 06510 USA

[7] Yale Sch Med, Dept Lab Med, New Haven, CT 06510 USA

[8] Yale Univ, Dept Ecol & Evolutionary Biol, New Haven, CT 06510 USA

[9] Univ Birmingham, Inst Microbiol & Infect, Birmingham B15 2TT, W Midlands, England

[10] Univ Washington, Dept Lab Med, Seattle, WA 98195 USA

[11] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98109 USA

[12] Yale Univ, Dept Immunobiol, New Haven, CT 06510 USA

[13] Howard Hughes Med Inst, Chevy Chase, MD 20815 USA

[14] Yale Univ, Yale Inst Global Hlth, New Haven, CT 06510 USA

[15] Yale Sch Med, Dept Med, Sect Infect Dis, New Haven, CT 06510 USA

[16] Yale Univ, Yale Sch Nursing, New Haven, CT 06510 USA

[17] St Michaels Hosp, Li Ka Shing Knowledge Inst, Toronto, ON M5B 1A6, Canada

[18] Univ Toronto, Dept Med, Sect Infect Dis, Toronto, ON M5S 3H2, Canada

[19] Yale Sch Med, Dept Pediat, New Haven, CT 06510 USA

[20] Yale New Haven Hlth, Dept Infect Prevent, New Haven, CT 06510 USA

[21] Yale New Haven Hlth, Clin Virol Lab, New Haven, CT 06510 USA

来源：

CELL | 2020年 / 181卷 / 05期

基金：

加拿大健康研究院; 英国惠康基金; 英国医学研究理事会;

关键词：

coronavirus; COVID-19; genomic epidemiology; MinION sequencing; phylogenetics; SARS-CoV-2; travel risk;

D O I：

10.1016/j.cell.2020.04.021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The novel coronavirus SARS-CoV-2 was first detected in the Pacific Northwest region of the United States in January 2020, with subsequent COVID-19 outbreaks detected in all 50 states by early March. To uncover the sources of SARS-CoV-2 introductions and patterns of spread within the United States, we sequenced nine viral genomes from early reported COVID-19 patients in Connecticut. Our phylogenetic analysis places the majority of these genomes with viruses sequenced from Washington state. By coupling our genomic data with domestic and international travel patterns, we show that early SARS-CoV-2 transmission in Connecticut was likely driven by domestic introductions. Moreover, the risk of domestic importation to Connecticut exceeded that of international importation by mid-March regardless of our estimated effects of federal travel restrictions. This study provides evidence of widespread sustained transmission of SARS-CoV-2 within the United States and highlights the critical need for local surveillance.

引用

页码：990 / +

页数：12

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