Effect of Lactobacillus GG supplementation on pulmonary exacerbations in patients with cystic fibrosis:: A pilot study

Background Et aims: Probiotics reduce intestinal inflammation in children with cystic fibrosis (CF). We want to determine the effects of Lactobacillus GG (LGG) on pulmonary exacerbations in CF. Methods: A prospective, randomized, placebo-controlled, cross-over study was performed. Nineteen children received LGG for 6 months and then shifted to oral rehydration solution (ORS) for 6 months. In parallel nineteen received ORS and then shifted to LGG. Main outcome parameters were: incidence of pulmonary exacerbations and of hospital admissions, forced expiratory volume (FEV1), and modifications of body weight. Results: Patients treated with LGG showed a reduction of pulmonary exacerbations (Median 1 vs. 2, range 4 vs. 4, median difference 1, CI 95% 0.5-1.5; p = 0.0035) and of hospital admissions (Median 0 vs. 1, range 3 vs. 2, median difference 1, C195% 1.0-1.5; p = 0.001) compared to patients treated with ORS. LGG resulted in a greater increase in FEV1 (3.6% +/- 5.2 vs. 0.9% +/- 5; p=0.02) and body weight (1.5kg +/- 1.8 vs. 0.7kg +/- 1.8; p = 0.02). Conclusions: LGG reduces pulmonary exacerbations and hospital admissions in patients with CF. These suggest that probiotics may delay respiratory impairment and that a relationship exists between intestinal and pulmonary inflammation. (c) 2007 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.